The maintenance of brain extracellular glutamate (Glu) at levels below its excitotoxic threshold is performed by Glu transporters present on glia and neurons as well as on brain capillary endothelial cells which remove brain Glu into blood. The feasibility of accelerating the naturally occurring brain-to-blood Glu efflux was studied using paradigms based on the fate of Glu present in the cerebr...

The present work examines the protective mechanisms of methanol extract of Oldenlandia umbellata (MEOU) in carbon tetrachloride intoxicated rats. Rats were treated with carbon tetrachloride at the dose of 1 ml/kg body weight intraperitonially once in every 72 hrs for 16 days. The hepatoprotective activity of methanol extract of Oldenlandia umbellata was evaluated by measuring levels of serum ma...

the present work examines the protective mechanisms of methanol extract of oldenlandia umbellata (meou) in carbon tetrachloride intoxicated rats. rats were treated with carbon tetrachloride at the dose of 1 ml/kg body weight intraperitonially once in every 72 hrs for 16 days. the hepatoprotective activity of methanol extract of oldenlandia umbellata was evaluated by measuring levels of serum ma...

Activ~ties of lactic dehydrogenase (LDH), glutamate oxaloacetate transanunase (GOT) and glutamate pyruvate transaminase (GPT) were measured in blood plasma and some tissues of grey mullet Mugd auratus Risso. After determination of optimal assay conditions, cardiac sampling for LDH estimation was recommended. Tissue distribution of enzymers and their origln in plasma were described, in particula...

Objective: Hepatoprotective activity of Punica granatum Linn. (Family: Punicaceae) was evaluated by in vitro and in vivo model. HepG2 cell lines were used for in vitro study and D-Galactosamine (D-GalN) induced hepatic damage model for in vivo evaluation. Methods: Hepatoprotective potential was assessed by measuring serum level of glutamate oxaloacetate transaminase, glutamate pyruvate transami...

A series of experiments, with Secale cereale and Triticum aestivum var Argee, to evaluate critically the ability of a malate/aspartate shuttle to provide reducing equivalents to drive hydroxypyruvate reduction to glycerate led to the conclusion that the shuttle, as previously envisioned, does not supply NADH to the peroxisomal matrix. First, analysis of coupled malate dehydrogenase and glutamat...