PURPOSE The main objective of the study was to formulate and characterize testosterone (TS) solid lipid microparticles (SLM) to be applied as a transdermal delivery system. METHODS Testosterone SLMs were formulated using an emulsion melt homogenization method. Various types and concentrations of fatty materials, namely glyceryl monostearate (GM), glyceryl distearate (GD), stearic acid (SA) an...

Abstract Purpose To prepare stable sustained-release (SR) pellets, containing high ibuprofen (IBU) loading, by hot-melt extrusion (HME) technique using polyethylene glycol 6000 (PEG 6000) and glyceryl monostearate (GMS). Methods HME pellets (60% w/w IBU) were prepared PEG 6000, GMS, mixture of both polymers (1:1). Stability studies performed under stress conditions (40 °C relative humidity “RH”...

Recently, therapeutic proteins have been used to combat life-threatening diseases. To date, oral routes developed deliver proteins. Since the proteolytic degradation in upper gastrointestinal tract frequently occurs, we need a formulation and strategy protect protein colon. In this research, solid lipid nanoparticles (SLNs) were prepared eight formulae for colon-targeted delivery with various g...

The purpose of the present study was to design and evaluate a novel wax matrix system containing various ratios of aminoalkyl methacrylate copolymer E (AMCE) and ethylcellulose (EC) as functional polymers in order to achieve the optimal acetaminophen (APAP) release rate for taste masking. A two factor, three level (3(2)) full factorial study design was used to optimize the ratios of AMCE and EC...

The objectives of this study are to demonstrate powder qualities foam-mat dried mango using different foaming agents and then compare drying method that the studies in other methods. Fresh puree Mahajanaka (Mangifera indica L.) grown north Thailand is mixed with glyceryl monostearate (GMS), sugar soybean isolated (SBI) ratios as agents, after at 70 °C a tray dryer for 5 h. color % foam overrun ...

In recent years, lipid-based nanosystems have emerged as a promising class of nanocarriers for encapsulating many active agents. Solid lipid nanoparticles (SLNs) provide good stability (colloidal well physical) and high biocompatibility. Appropriate design the carrier structure through selection components preparation methods allows us to obtain formulations with desired physicochemical paramet...

Abstract: Background: The aim of present study was to carry out the formulation design and evaluation Solid Lipid Nanoparticles (SLNs) loaded topical gel Flurbiprofen. Materials Methods: Flurbiprofen solid lipid nanoparticles were formulated using Glyceryl monostearate (GMS) as matrix by solvent evaporation method followed probe sonication. A 32 full factorial utilized optimize SLNs. Drug: rati...

Abstract: Background: Paliperidone is indicated for the treatment of schizophrenia. It has an absolute oral bioavailability about 28% as it poorly soluble in water and also undergoes hepatic first-pass metabolism. Objectives: The purpose present study to improve solubility, vitro paliperidone by formulating nanostructured lipid carrier (NLC). Materials Methods: High shear homogenization followe...