نتایج جستجو برای: glycolysis
تعداد نتایج: 10426 فیلتر نتایج به سال:
Cellular energy in the form of ATP can be produced through oxidative phosphorylation and through glycolysis. Since oxidative phosphorylation requires oxygen and generates ATP more efficiently than glycolysis, it has been assumed for many years that the presence or absence of oxygen determines that cel ls generate energy through ox idat ive phosphorylation or through glycolysis. Although cells m...
Differentiated podocytes, a type of renal glomerular cells, require substantial levels of energy to maintain glomerular physiology. Mitochondria and glycolysis are two major producers of ATP, but the precise roles of each in podocytes remain unknown. This study evaluated the roles of mitochondria and glycolysis in differentiated and differentiating podocytes. Mitochondria in differentiated podo...
A "switch" from oxidative phosphorylation (OXPHOS) to aerobic glycolysis is a hallmark of T cell activation and is thought to be required to meet the metabolic demands of proliferation. However, why proliferating cells adopt this less efficient metabolism, especially in an oxygen-replete environment, remains incompletely understood. We show here that aerobic glycolysis is specifically required ...
Zhou L, Huang H, McElfresh TA, Prosdocimo DA, Stanley WC. Impact of anaerobic glycolysis and oxidative substrate selection on contractile function and mechanical efficiency during moderate severity ischemia. Am J Physiol Heart Circ Physiol 295: H939–H945, 2008. First published July 25, 2008; doi:10.1152/ajpheart.00561.2008.—The role of anaerobic glycolysis and oxidative substrate selection on c...
That slices of tumor tissue will produce large amounts of lactic acid has been well known since the early studies in Warburg's laboratory in 192430 (10, 20). That tumor glycolysis involves the same intermediate pathway as found in normal tissues has, however, been frequently questioned, perhaps most recently by Salter who re-emphasized at the Hershey Conference on Intracellular Enzymes in Norma...
That slices of tumor tissue will produce large amounts of lactic acid has been well known since the early studies in Warburg's laboratory in 192430 (10, 20). That tumor glycolysis involves the same intermediate pathway as found in normal tissues has, however, been frequently questioned, perhaps most recently by Salter who re-emphasized at the Hershey Conference on Intracellular Enzymes in Norma...
Trastuzumab shows remarkable efficacy in treatment of ErbB2-positive breast cancers when used alone or in combination with other chemotherapeutics. However, acquired resistance develops in most treated patients, necessitating alternate treatment strategies. Increased aerobic glycolysis is a hallmark of cancer and inhibition of glycolysis may offer a promising strategy to preferentially kill can...
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