Glycosylation is an essential process by which sugars are attached to proteins and lipids. Complete lack of glycosylation is not compatible with life. Because of the widespread function of glycosylation, inherited disorders of glycosylation are multisystemic. Since the identification of the first defect on N-linked glycosylation in the 1980s, there are over 40 different congenital protein hypog...

alpha-1-proteinase inhibitor (api) is one of the acute phase proteins. following an inflammatory stimuli the concentration of api increased up to four folds. accompanying these quantitative changes, there is qualitative alterations in the structure of carbohydrate moiety (glycosylation). to determine the alterations in the glycosylation of api in inflammation, api was isolated from the sera of ...

conclusions this study provided conserved b-cell epitopes and peptides that can be useful for designing entry inhibitors and vaccines able to cover a global population, especially where genotype 5a is common. results differences in the probability of glycosylation in e1 and e2 regions were observed in this study. three conserved antigenic b-cell epitopes were predicted in the e2 regions and als...

conclusions our histochemical findings showed a relatively heavy glycosylation of syncytiotrophoblasts of both partial and complete molar tissues, which was prominent in apical portion. this may play a role in their capacity to increase trophoblastic proliferation. results the partial and complete moles generally showed similar reactivity with all used lectins. none of lectins reacted with vill...

Congenital disorders of glycosylation (CDGs) are a family of N-linked glycosylation defects associated with severe clinical manifestations. In CDG type-I, deficiency of lipid-linked oligosaccharide assembly leads to the underoccupancy of N-glycosylation sites on glycoproteins. Although the level of residual glycosylation activity is known to correlate with the clinical phenotype linked to indiv...

Statistical analysis was carried out to study the sequential aspects of amino acids around the O-glycosylated Ser/Thr. 992 sequences containing O-glycosylated Ser/Thr were selected from the O-GLYCBASE database of O-glycosylated proteins. The frequency of occurrence of amino acid residues around the glycosylated Ser/Thr revealed that there is an increased number of proline residues around the O-...

Glycosylation is a complex post-translational modification that conveys functional diversity to glycoconjugates. Cell surface glycosylation mediates several biological activities such as induction of the intracellular signaling pathway and pathogen recognition. Red blood cell (RBC) membrane N-glycans determine type influence lifespan. Although proteomic studies have been carried out, RBC protei...

Elevated plasma levels of the biomarker soluble urokinase plasminogen activator receptor (suPAR) are prognostic adverse outcomes in cardiovascular disease (CVD). This novel inflammatory protein has five known N-linked glycosylation sites, but contribution to progression is unknown. study aimed assess impact on suPAR measurements. Bio-banked samples from healthy volunteers and patients with CVD ...

Congenital disorders of glycosylation (CDG) and mitochondrial are multisystem with overlapping symptomatology. Pathogenic variants in the PMM2 gene lead to abnormal N-linked glycosylation. This disruption can induce endoplasmic reticulum stress, contributing disease pathology. Although impaired dysfunction has been reported some CDG, cellular bioenergetics never evaluated detail PMM2-CDG. promp...

Glycosylation can be a promising tool for engineering protein-based biomaterials specifically regarding adhesion.