A variety of transgenic animal models has been developed to elucidate in vivo the functions of gonadotrophin genes. Some of these have focused on regulatory aspects through expression of gonadotrophin subunit promoter-driven reporter genes. Others have been carried out by overexpression or targeted disruption of specific gonadotrophin subunit genes, or by eliminating pituitary gonadotroph cells...

It is generally believed that exogenously administered A.C.T.H. and corticosteroids suppress the secretion of endogenous A.C.T.H. and possibly also of thyroid-stimulating hormone and growth hormone (Ackerman, Smith, and Miller, 1961; Hartog, Gaafar, and Fraser, 1964; Graber, Ney, Nicholson, Island, and Liddle, 1965). However, information regarding the effect of these forms of treatment on pitui...

BACKGROUND Non-invasive screening investigations are rarely used for assessing the activation and progression of the hypothalamic-pituitary gonadal axis through puberty. This study aimed to establish a normal range for urinary gonadotrophins in children progressing through puberty. METHODS Urine samples were collected from 161 healthy school children (76 boys, 85 girls) aged 4-19 yrs. Height ...