OBJECTIVES The objective of this study was to investigate the association between platelet glycoprotein (GP) Ia C807T polymorphisms and ischemic stroke in young Chinese Han Population. MATERIALS AND METHODS We conducted a case-control study in 92 consecutive young ( 50 years), ...

Receptor Polymporphisms? Not in the Real World To the Editor: We read with interest the article by Pontiggia et al,1 discussing the possible functional implications of double homozygosity for two “prothrombothic” platelet glycoprotein receptor polymorphisms (Pl of GpIIIa and C807T of GpIa) in a family with a strong history of premature cardiovascular events. We would like to report our experien...

OBJECTIVE There is considerable controversy regarding the clinical role of the single-nucleotide polymorphisms (SNPs) of the platelet glycoprotein receptor GPIa C807T and the Pl(A1/A2) of GPIIIa as cardiovascular risk factors. We hypothesized that two combined SNPs in their homozygous prothrombotic forms could clarify their pathophysiological impact. METHODS AND RESULTS We identified a family...

Recently, we have shown that two alleles of the glycoprotein (GP) Ia gene, designated C807 and T807, are associated with low or high platelet GPIa-IIa density and consequently with slower or faster rate of platelet adhesion to type I collagen, respectively. This polymorphism could therefore present a genetic predisposition for the development of thrombotic disease and hemostasis. We investigate...

This study investigates whether the polymorphisms of 3 important platelet receptors affected experimental thrombus formation in men. Forty healthy male volunteers randomly recruited were genotyped for the variable number of tandem repeat (VNTR) of GPIbalpha, the -5T/C polymorphism in the Kozak sequence of GPIbalpha, the 807C/T polymorphism of GPIa, and the PI(A1)/PI(A2) polymorphism of GPIIb/II...

Recently, we have shown that two alleles of the glycoprotein (GP) Ia gene, designated C807 and T807, are associated with low or high platelet GPIa-IIa density and consequently with slower or faster rate of platelet adhesion to type I collagen, respectively. This polymorphism could therefore present a genetic predisposition for the development of thrombotic disease and hemostasis. We investigate...

This study investigates whether the polymorphisms of 3 important platelet receptors affected experimental thrombus formation in men. Forty healthy male volunteers randomly recruited were genotyped for the variable number of tandem repeat (VNTR) of GPIba, the 25T/C polymorphism in the Kozak sequence of GPIba, the 807C/T polymorphism of GPIa, and the PlA1/PlA2 polymorphism of GPIIb/ IIIa. Platele...

Receptor Polymporphisms? Not in the Real World To the Editor: We read with interest the article by Pontiggia et al,1 discussing the possible functional implications of double homozygosity for two “prothrombothic” platelet glycoprotein receptor polymorphisms (Pl of GpIIIa and C807T of GpIa) in a family with a strong history of premature cardiovascular events. We would like to report our experien...