Disparity for HLA in unrelated donor bone marrow transplantation (BMT) increases the risk of graft rejection and graftversus-host disease (GVHD) and may compromise transplant outcome. We have compared the outcome of matched and mismatched transplants from unrelated donors in 137 children with acute lymphoblastic leukemia (ALL). Their disease status was complete remission (CR)-1, 24 patients; CR...

In this paper, a new approach for optimizing disparity candidates space is proposed for the solution of dense stereo matching problem. The main objectives of this approachare the reduction of average number of disparity candidates per pixel with low computational cost and high assurance of retaining the correct answer. These can be realized due to the effective use of multiple radial windows, i...

The dioptric power of the cornea (spherical equivalent) was studied in 60 eyes operated on for penetrating keratoplasty. In order to determine the possible influence of (1) the underlying pathology, (2) the presence of neovascularisation, or (3) the size of the graft the sample was divided into four groups, with the following results: group A (keratoconus, same-sized graft) = 42.25 D; group B (...

Previous reports have indicated that HLA-D disparity as reflected by the mixed lymphocyte culture (MLC) test is important in living related renal transplantation, and this test could predict the outcome of 1-haplotype matched renal transplants 1-6. The clinical outcome of 73 patients who received living related grafts between 1978 and 1981 was reviewed, and graft survival correlated with the ML...

Allogeneic bone marrow transplantation (BMT)' has become a major therapeutic modality in the treatment of various malignant and nonmalignant hematologic disorders (1-6) . However, graft-vs.-host disease (GuHD) causes much morbidity and mortality after transplantation (7, 8) . Since GvHD is mediated by immunocompetent T cells in the graft (9, 10), depletion of T cells from the bone marrow graft ...

Although corneal transplantation is performed on patients with densely vascularized corneas, the likelihood of immunologic rejection is greater than in the nonvascularized cornea. In other organ transplantation systems, immune rejection has been correlated with the degree of antigenic disparity of the major histocompatibility antigens (HL-A) between the donor and the recipient. In this study, w...

BACKGROUND African American transplant recipients have poorer long-term outcomes than Caucasian Americans. This difference was not found in French patients, suggesting socialized medicine overcame this disparity. It has also been hypothesized that the difference relates to the higher prevalence of Black individuals who express the metabolic enzyme cytochrome P4503A5 (CYP3A5), with consequent al...

One hundred twelve patients less than 36 years old received marrow grafts from unrelated donors as treatment for hematologic malignancy. Seventy donor/recipient pairs were phenotypically identical for HLA-A, -B, and -D, while 42 had a "minor" disparity at one HLA locus. There was an increase in the risk of acute graft-versus-host disease (GVHD) in patients receiving HLA-partially matched grafts...

K h e ABSTRACT: The occurrence of graft rejection episodes after orthotopic liver transplantation (OLT) despite the use of immunosuppressive drugs designed to suppress T lymphocyte functions, indicates the involvement of other types of cells in this process. The activity of natural killer cells and their killer immunoglobulin-like receptors (KIR) is regulated by human leukocyte antigen (HLA) cl...