Sepsis is a life-threatening organ dysfunction caused by disturbed response to infection. The development of sepsis preceded Systemic Inflammatory Response Syndrome (SIRS), which the overall inflammatory body severe lesion. role opportunistic pathogens in CER and may be considered proven, but value intestinal microbiome remains underestimated. survey systematized data on cell wall or membrane c...

INTRODUCTION In our clinical practice, we observed high interleukin-6 (IL-6) levels in gram-negative sepsis. OBJECTIVE To investigate the relationship between IL-6 and C-reactive protein (CRP) levels and early determination of neonatal sepsis of gram-negative or gram-positive aetiology. POPULATION AND METHODS White blood cell count, IL-6 and CRP levels were compared among different groups. ...

background sepsis can be defined as the body’s response to an infection. sepsis in children remains a significant cause of morbidity and mortality worldwide. objectives this study focuses on the etiological factors, risk factors, and clinical characteristics of sepsis in neonate and pediatric patients. patients and methods a prospective study was conducted over a six-month period in the pediatr...

We performed a prospective study to evaluate the abilities of inflammatory cytokines to rule out the potential risk of sepsis and intracranial infection and to estimate the function of inflammatory cytokines in discriminating Gram-negative bacteria from Gram-positive ones through ROC analysis. During the course of the study, Levels of serum inflammatory cytokines were measured by flow cytometry...

BACKGROUND Lipopolysaccharide (endotoxin) from the cell wall of Gram-negative bacteria is a potent trigger for the release of host-derived inflammatory mediators. The relationship between endotoxaemia, Gram-negative infection and the clinical syndrome of sepsis has been difficult to establish, in part because of the limitations of available endotoxin assays. METHODS We performed an observatio...

Bacterial sepsis is a major cause of fatality worldwide. Sepsis is a multi-step process that involves an uncontrolled inflammatory response by the host cells that may result in multi organ failure and death. Both gram-negative and gram-positive bacteria play a major role in causing sepsis. These bacteria produce a range of virulence factors that enable them to escape the immune defenses and dis...

Neonatal sepsis is a life-threatening emergency, and any delay in treatment may cause death. Because of the importance of the problem in Iran, the aim of this retrospective study was to determine the etiological agents of neonatal septicemia, and the prevalence and epidemiology of Klebsiella bacteremia in the neonatal wards. Two hundred and ten cases of neonatal sepsis occurred during the study...