While localized variants of granuloma annulare are typically self-limited, disseminated granuloma annulare tends to be chronic and often therapy-resistant. Treatment with fumaric acid esters is effective for severe forms of psoriasis. Disseminated granuloma annulare has also been reported to respond to fumaric acid esters. We treated 8 patients (mean age 64.2 years; 4 men, 4 women) with low-dos...

Erythema annulare centrifugum is a figurate erythema of unknown etiology. It has been associated with many different entities, including infections, food allergy, drug reactions and malignant neoplasms. Herein, we report a case of erythema annulare centrifugum as presenting sign of activation of breastcancer.

Simultaneous occurrence of granuloma annulare and necrobiosis lipoidica is quite rare. There are seven reported cases in the literature, but only one presenting ulcerated necrobiosis lipoidica. We report a 39-year-old male with histopathologically confirmed granuloma annulare and ulcerated necrobiosis lipoidica, without diabetes mellitus.

A 73-year-old Caucasian female patient presented for three annular erythematous lesions on the left leg and buttock, persisting for two months, clinically interpreted as erythema annulare centrifugum. Routine laboratory findings were within the normal ranges, Borrelia serology and wet mount microscopy for mycosis were negative. Histologic examination confirmed the diagnosis of superficial eryth...

Granuloma annulare is a benign, relatively common dermatosis of childhood and young adults. Lesions typically occur on the extremities. Localized facial and periocular involvement is rare. We describe a 25- year-old woman with asymptomatic skin-color, firm, and papular lesions on both periocular areas since 6 months ago. Histological examination revealed palisading necrobiotic granuloma, charac...

even in old age. No patient had granuloma annulare at last examination. Interesting comorbidities are listed in the Table. Most patients with conditions or diseases had only ordinary ones such as hypertension, hyperlipidemias, degenerative joint disease, and atherosclerosis. In summary, patients who develop granuloma annulare usually heal, remain remarkably healthy, and do not ordinarily develo...

Granuloma annulare is a benign, asymptomatic, self-limited papular eruption found in patients of all ages. The primary skin lesion usually is grouped papules in an enlarging annular shape, with color ranging from flesh-colored to erythematous. The two most common types of granuloma annulare are localized, which typically is found on the lateral or dorsal surfaces of the hands and feet; and diss...

In the winter of 1959-1960 the number of patients with acute rheumatism who applied to our Centre for treatment was larger than in former years, and most cases presented with a forme fruste of the condition. The three cases reported differed from the others in that they presented with erythema annulare (EA). The chief outward sign of erythema annulare is a series of rings about 2 mm. wide, with...

Simultaneous occurrence of granuloma annulare and necrobiosis lipoidica is quite rare. There are seven reported cases in the literature, but only one presenting ulcerated necrobiosis lipoidica. We report a 39-year-old male with histopathologically confirmed granuloma annulare and ulcerated necrobiosis lipoidica, without diabetes mellitus.