Insulin receptor substrate-1 (Irs1) is one of the major substrates for insulin and insulin-like growth factor-1 (IGF-1) tyrosine kinases. Systemic Irs1-deficient mice show retardation, with resistance to IGF-1, although underlying mechanisms remain poorly understood. For this study, we generated brain-specific deletion Irs1 (NIrs1KO mice). The NIrs1KO exhibited lower body weights, shorter bodie...

The purpose of this study was to investigate the involvement of growth hormone in the diurnal variation of insulin sensitivity in healthy adults. Afternoon (16:00 hr) or night (23:00 hr) pretreatment with a subcutaneous injection of normal saline, human growth hormone to mimic the normal nocturnal rise in growth hormone, or octreotide to inhibit endogenous growth hormone secretion to create a s...

Background & Aims: puberty is a process in which physical and physiological changes lead to changes in the child's body as an adult with reproductive capacity. The purpose of the present study was to investigate the effect of 12 weeks of moderate intensity aerobic training on serum leptin, growth hormone / Insulin-Like Growth Factor-1, in Mature and immature Inactive Girl Students. Materials &...

conclusions igf-1 has the most significant effect on intrauterine growth. acylated ghrelin is detectable in cord blood and correlated with birth weight, suggesting a role in intrauterine development, but its level is not affected by intrauterine growth retardation. results no significant differences were observed in ghrelin and gh concentrations between sga and aga infants. however, igf-1 level...

background the physiological link between ghrelin and growth hormone (gh) has not yet been fully clarified. furthermore, the existence of a negative feedback mechanism between growth hormone–insulin-like growth factor (gh–igf)-i axis and ghrelin and the influence of amino acids on ghrelin secretion in children remain matters of debate. objectives to understand the regulation of ghrelin secretio...

kaatsu training is effective and beneficial to improve different physical factors and is associated with lower muscular injury and inflammation. so, the aim of this study was to compare the effect of kaatsu training and no blood flow restriction on changes of growth hormone, insulin-like growth factor-1 and lactate in healthy young men. this study was semi-experimental with a repeated measureme...

The effect of insulin on the incorporation of radioactive leucine into growth hormone was investigated by using rat anterior pituitary glands incubated in vitro. A 50% stimulation over control values was observed at insulin concentrations above 2mum (280munits/ml). The effect was specific for growth hormone biosynthesis, over the range 1-5mum-insulin (140-700munits/ml). Lower more physiological...