The vesicular adenosine triphosphatase (ATPase) acidifies intracellular compartments, including synaptic vesicles and secretory granules. A controversy about a second function of this ATPase in exocytosis has been fuelled by questions about multiple putative roles of acidification in the exocytic process. Now, Poëa-Guyon et al. (2013. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201303104) prese...

We organized a Challenge to unravel the connectivity of simulated neuronal networks. The provided data was solely based on fluorescence time series of spontaneous activity in a network constituted by 1000 neurons. The task of the participants was to compute the effective connectivity between neurons, with the goal to reconstruct as accurately as possible the ground truth topology of the network...

OBJECTIVE To present the clinical diagnostic features including management of Guyon canal syndrome in a case with unresolved sensory deficits in a young female cyclist. CLINICAL PRESENTATION After 14 days of cycling across Canada, a 23-year old female experienced sensory loss, followed by atrophy and a "claw" hand appearance of her left hand. INTERVENTION AND OUTCOME Treatment included cerv...

OBJECTIVE To determine the diagnostic cutoff values of ultrasonographic measurements in ulnar neuropathy at the elbow (UNE). METHODS Twenty-five elbows of 23 patients (9 females, 16 males) diagnosed with UNE and 30 elbows of 30 healthy controls (15 females, 15 males) were included in our study. The ulnar nerve cross-sectional area (CSA) was measured at the Guyon canal, midforearm, and maximal...

OBJECTIVE The aim of this study was to investigate the usefulness of high-resolution ultrasonography for the diagnosis of polyneuropathy in diabetes mellitus patients by the examination of the ulnar nerves. METHOD We recruited 100 healthy age-matched volunteers (50 women and 50 men) with 200 arms without diabetes or cubital tunnel syndrome as the control group. We assessed the upper limbs of ...

High dimension data analysis has become a challenging problem in modern sciences. The diagnosis by gene expression or SNPs data arising in medical and biological sciences is a typical example and may be the most important focus of the research in the past decade. The number of variables in these data sets may be tens to hundreds of thousands. The understanding of the data structure and inferenc...