OBJECTIVE Patient chances for cure and palliation for a variety of malignancies may be greatly affected by the care provided by a treating hospital. We sought to determine the effect of volume and teaching status on patient outcomes for five gynecologic malignancies: endometrial, cervical, ovarian and vulvar carcinoma and uterine sarcoma. METHODS The Florida Cancer Data System dataset was que...

usual gynecologic malignancy that accounts for less than 1% of all malignancies of the female genitalia (1). Among them, papillary serous adenocarcinoma appears to be the most common histologic type (2). Endometrial cancer is one of the common gynecologic malignancies. Most endometrial cancers are endometrioid adenocarcinomas and only approximately 10% are uterine papillary serous carcinomas (3...

The present clinical trial is of high scientific interest, as pelvic lymphadenectomy is a very common procedure in women with gynecologic malignancies. Lymphoceles are one of the major complications after pelvic lymphadenectomies. Symptomatic lymphoceles typically require medical interventions and lead to reduced quality of life and increased patient’s discomfort. Additionally, they can also ca...

Altered surface glycosylation is a key feature of cancers, including gynecologic malignancies. Hypersialylation, the overexpression of sialic acid, is known to promote tumor progression and to dampen antitumor responses by mechanisms that also involve sialic acid binding immunoglobulin-like lectins (Siglecs), inhibitory immune receptors. Here, we discuss the expression patterns of Siglecs and s...

Traditionally, and according to actual guidelines, [1] cancers affecting female genital organs are treated with radical surgery, chemotherapy, radiation therapy or a combination of the above mentioned, all bearing a permanent damage of the female reproductive tract. Anyway, facing with a continuous trend in postponing childbearing and the early detection of gynecologic cancers, there has been a...

the discovery of x-rays by Roentgen and radium by the Curies, the first patient was treated with therapeutic x-rays. During the first few decades of the 20th century, the use of radiation increased significantly. The earliest uses of therapeutic radiation often involved treating gynecologic malignancies. Over the next one hundred years, radiation therapy became one of the integral treatment app...

Objective: Brain Metastasis (BM) from primary gynecologic cancers is a rare entity. The advances and successes in the treatment of primary gynecologic malignancies, have led to prolonged survival and, a higher incidence of BM. This study aims to report the experience at our institution in managing these patients, and provide possible data points that may be essential to note as prognostic facto...