background and aims: there has been scant information concerning antihypertrophic effects of vitamin d specifically on its cellular and molecular mechanisms. sirtuin 1 (sirt1) is regarded as a key deacetylase enzyme in cardiomyocytes which applies potential cardioprotective effects by functional regulation of different proteins. this study aimed to evaluate the effects of 1, 25-dihydroxyvitamin...

Background Non-Steroidal Anti-Inflammatory Drugs(NSAIDs) including Ibuprofen is one of the most currently used drugs in all age groups and finding the relation between upper gastrointestinal bleeding and Helicobacter pylori (H. pylori) in children who used Ibuprofen, is our topic of research. Materials and Methods During the two years of the study, ten children with upper GI bleeding after Ibup...

heparin has an unpredictable pharmacokinetics and the responses of individuals may vary distinctly. therefore, different dosing nomograms have been proposed. the aim of this study was to compare two prevalent nomograms to adjust heparin doses in hospitalized patients with acute coronary syndrome.  one hundred and forty patients received heparin infusions based on one of two nomograms. group 1 r...

in this study we use the p receiver function technique to determine the moho depth and vp/vs ratio for 8 short period stations of qochan and mashhad seismic networks and map the variations of moho depth under kope dagh region. it is shown that a receiver function can provide a relatively good point measurement of moho depth under a short period station. the crustal thickness estimated from the ...

The prevention of BBB breakdown and the subsequent vasogenic edema are important parts of the medical management of ischemic stroke. The purpose of this study was to investigate the ischemic tolerance effect of Rosmarinus officinalis leaf hydro-alcoholic extract (RHE).Five groups of animals were designed: sham (underwent surgery without MCAO) and MCAO groups, the MCAO groups were pretreated ora...

  Various recent studies in both human and laboratory animals have indicated an influential role of glucose and phosphate in embryonic development of different strains and species in various media. So this study was initiated to investigate the effects of different concentrations of glucose (G0=0, Gl=0.2, G2=5.5 mM) in the absence (P0) and presence (P1=0.39 mM) of inorganic phosphate, designate...

The prevention of BBB breakdown and the subsequent vasogenic edema are important parts of the medical management of ischemic stroke. The purpose of this study was to investigate the ischemic tolerance effect of Rosmarinus officinalis leaf hydro-alcoholic extract (RHE).Five groups of animals were designed: sham (underwent surgery without MCAO) and MCAO groups, the MCAO groups were pretreated ora...

Background: It is clear that Helicobacter pylori (H. pylori) is a spiral bacterium that infects human and causes gastritis and peptic ulcer. The aim of this study was to determine the relationship between H .pylori infection and the iron status of the body. Methods: This study was conducted in Shahid Beheshti Hospital of Babol University of Medical Sciences, Babol, Iran from August 2007 to July...