The human asialoglycoprotein receptor, an endocytic transport receptor of the basolateral surface of hepatocytes, is a hetero-oligomer of two homologous subunits H1 and H2. The cytoplasmic domain of H1 has been shown previously to contain a tyrosine-based signal for endocytosis and basolateral sorting. Here, we have investigated sorting determinants within subunit H2 and their contribution to t...

Given two graphs H1 and H2, a graph G is (H1,H2)-free if it contains no subgraph isomorphic to H1 or H2. We continue a recent study into the clique-width of (H1,H2)-free graphs and present three new classes of (H1, H2)-free graphs that have bounded clique-width. We also show the implications of our results for the computational complexity of the Colouring problem restricted to (H1,H2)-free grap...

In barley (Hordeum vulgare), PHOTOPERIOD1 (Ppd-H1) acts as a major positive regulator of flowering under long-day conditions, while VERNALIZATION2 (VRN-H2) is a strong repressor of flowering under long days before vernalization. By contrast, CONSTANS (CO) plays a key role in the photoperiodic regulation of flowering in Arabidopsis (Arabidopsis thaliana). Here, we study the role of the closest b...

Biomolecular recognition entails attractive forces for the functional native states and discrimination against potential nonnative interactions that favor alternate stable configurations. The challenge posed by the competition of nonnative stabilization against native-centric forces is conceptualized as frustration. Experiment indicates that frustration is often minimal in evolved biological sy...

Neurofibrillary tangles composed of exon 10+ microtubule associated protein tau (MAPT) deposits are the characteristic feature of the neurodegenerative diseases progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). PSP, CBD and more recently Alzheimer's disease and Parkinson's disease, are associated with the MAPT H1 haplotype, but the relationship between genotype and disea...

The relative magnitude of the first two harmonics of the voice source (H1*-H2*) is an important measure and is assumed to be one exponent of changes in vocal quality along a breathyto-pressed continuum. H1*-H2* is often associated with glottal open quotient (OQ) and glottal pulse skewness (as quantified by speed quotient, SQ), but may also covary with fundamental frequency (F0) and vocal intens...

The ArcB and ArcA proteins constitute a two-component signal transduction system that plays a broad role in transcriptional regulation. Under anoxic or environmentally reducing conditions, the sensor kinase (ArcB) is stimulated to autophosphorylate at the expense of ATP and subsequently transphosphorylates the response regulator (ArcA). ArcB is a complex, membrane-bound protein comprising at le...

Proof. Clearly, the image of F is HK by definition. To see that F is injective, suppose that F (h1, k1) = F (h2, k2). Then by definition h1k1 = h2k2. Thus h −1 2 h1 = k2k −1 1 . Since H is a subgroup, h−1 2 h1 ∈ H, and since K is a subgroup, k2k −1 1 ∈ K. Thus h−1 2 h1 = k2k −1 1 ∈ H ∩ K = {1}, and so h −1 2 h1 = k2k −1 1 = 1. It follows that h−1 2 h1 = 1, so that h1 = h2, and similarly k2k −1 ...

Perilipins regulate triacylglycerol storage and hydrolysis in adipocytes. The central 25% of the perilipin A sequence, including three hydrophobic sequences (H1, H2, and H3) and an acidic region, targets and anchors perilipins to lipid droplets. Thus, we hypothesized that H1, H2, and H3 are targeting and anchoring motifs. We now show that deletion of any single hydrophobic sequence or combinati...

a water snake (natrix natrix) was referred to the small animal teaching hospital, faculty of veterinary medicine, university of tehran. it had two subcutaneous masses. radiographic and ultrasonographic images revealed the presence of two subcutaneous abscesses. the abscesses were removed surgically and specimens were examined by conventional microbial culture and multiplex pcr. inv-a universal ...