Abstract Summary Untargeted metabolomics data analysis is highly labor intensive and can be severely frustrated by both experimental noise redundant features. Homologous polymer series are a particular case of features that either represent large numbers features, or alternatively interest with peak redundancy. Here we present homologueDiscoverer, an R package which all...

Research Objectives To investigate the association between veteran socio-demographics and clinical factors with likelihood of having a Traumatic Brain Injury (TBI), TBI survival Veterans Health Administration (VHA) costs. Design A retrospective study veterans diagnosed age-matched cohort without were followed 2000-2015. Setting using VHA Medical Centers Community Base...

Objective To provide evidence-based recommendations to practicing physicians and others regarding the efficacy of oocyte cryopreservation (OC) for donor in vitro fertilization planned OC. Methods The American Society Reproductive Medicine conducted a literature search, which included systematic reviews, meta-analyses, randomized controlled trials, prospective retrospective com...

AbstractBackground Bariatric surgery has been found to be effective in the treatment of severe obesity. Studies have shown that majority eligible patients do not undergo surgery. Objectives It is important identify variables may impact patient decision making and potentially lead disproportionate underutilization bariatric Setting The study was conducted at o...

Background Analysis of injury and illness prevalence in elite sport provides the basis for development prevention programmes. Objectives To analyse frequency characteristics injuries illnesses occurring during 13th Federation Internationale de Natation (FINA) World Championships 2009. Design Prospective recording newly incurred illnesses. Methods The FINA hos...

AbstractObjectives Previous studies have shown low to moderate evidence for a variety of magnetic resonance imaging (MRI) features as prognostic factors in athletes with hamstring injuries. Short-tau inversion recovery (STIR) signal intensity has not yet been investigated assessing the prognosis acute muscle Our aim was explore relationship between MRI STIR and time return pla...

Abstract Objective To determine the continuity of care (CoC) provided by general practitioners among workers with low back pain; identify personal, workplace and social factors associated CoC in this population; investigate if is working time loss. Data sources An administrative database containing accepted workers’ compensation claim service level data, for pain from...

Context: Tapering of long-term opioid therapy (LTOT) increased after publication the 2016 CDC guidelines, followed by anecdotal reports exacerbated pain among tapered patients. However, two systematic reviews limited evidence from multidisciplinary control programs found similar or better ratings tapering versus baseline. Objective: To evaluate association between dose and sub...

Context: Digital therapeutics may be uniquely positioned to address challenges reported by providers in chronic pain (CP) management. Previous studies have shown patient-provider discordance priorities for CP management, which can addressed digital development encourage implementation and use. Objective: To assess primary care providers’ patients’ perceptions of treatment goal...

In the present paper we report the genomic organization of the human histamine H3-receptor gene, which consists of four exons spanning 5.5 kb on chromosome 20. Using PCR, six alternative splice variants of the H3 receptor were cloned from human thalamus. These variants were found to be coexpressed in human brain, but their relative distribution varied in a region-specific manner. These isoforms...