INTRODUCTION i.v. haloperidol is used commonly for sedation in critically ill patients. However, i.v. haloperidol has been shown to cause the life-threatening ventricular tachyarrhythmia torsades de pointes. Mechanisms by which haloperidol causes torsades de pointes have not been widely investigated in controlled studies. STUDY OBJECTIVES To determine the effects of i.v. haloperidol on electr...

Haloperidol, a classical antipsychotic drug, affects the extracellular signal-regulated kinase (ERK) pathway in the brain. However, findings are inconsistent and the mechanism by which haloperidol regulates ERK is poorly understood. Therefore, we examined the ERK pathway and the related protein phosphatase 2A (PP2A) in detail after haloperidol administration. Haloperidol (0.5 and 1 mg/kg) induc...

Haloperidol is an antipsychotic drug that inhibits the dopamine D2 receptor among others. Haloperidol also binds the sigma-1 receptor (σ1R) and inhibits it irreversibly. A serious outcome of haloperidol treatment of schizophrenia patients is death due to sudden cardiac failure. Although the cause remains unclear, we hypothesized that these effects were mediated by chronic haloperidol inhibition...

Background: The association of delirium with poor outcomes creates a complex picture in traumatic brain injury patients by exacerbating an already increased risk for neurobehavioral sequelae. Haloperidol is commonly used for agitation and delirium; however, adverse events are concerns associated with its use in traumatic brain injury patients. The objective of this study was to assess the safet...

background and objective: today, opioids are used to control and relieve acute and chronic pain. however, the incidence of both tolerance and dependence phenomena for these drugs is a major problem. so, in this study, the combination effect of haloperidol and methadone on the acquisition and expression of morphine dependence and tolerance was examined.    materials and methods: ninety-eight mic...

background: the aim of this study was to compare the effects of olanzapine versus haloperidol to control the signs and symptoms of stuttering. methods: ninety‑three patients were recruited in a 12‑week single‑blind randomized clinical trial, which was held between october 2009 and october 2010. forty‑three patients received olanzapine (5 mg/day) and 50 patients, haloperidol (2.5 mg/day). before...

Haloperidol is a neuroleptic drug used for a medication of various psychoses and deliria. Its administration is frequently accompanied by cardiovascular side effects, expressed as QT interval prolongation and occurrence of even lethal arrhythmias. Despite these side effects, haloperidol is still prescribed in Europe in clinical practice. Haloperidol binds to sigma receptors that are coupled wit...

OBJECTIVES To evaluate the clinical effectiveness, safety, and cost of dexmedetomidine for the treatment of agitated delirium refractory to haloperidol in nonintubated critically ill patients. DESIGN Nonrandomized, controlled trial. SETTING Intensive care department of a tertiary care nonprofit hospital. PATIENTS All consecutive admissions to a medical-surgical ICU with a diagnosis of agi...

The interactions of compound ZDM-81 with some CNS neurotransmitter systems were studied using in vivo methods to evaluate the interaction dopaminergic (catalepsy, induced haloperidol), adrenergic (clonidine hypothermia), GABAergic (test flumazenil) and serotonergic (5-hydroxytryptophan hyperkinesis) systems. It was shown that is able prolong potentiate effects 5-hydroxytryptophan, reduces catal...