background: gestational diabetes mellitus (gdm) is common during pregnancy. this survey was designed based on the frequency of gdm among an urban population according to the american diabetes association (ada) and the international association of diabetes and pregnancy study groups (iadpsg) criteria.   methods : we included all pregnant women who were admitted to a gynecology clinic from septem...

Hemangiopoietin (HAPO) is a novel growth factor stimulating the proliferation of hematopoietic and endothelial progenitor cells in vitro and in vivo. The native protein is a 294‑amino acid multimodular protein. The N‑terminus constitutes of two somatomedin B (SMB) homology domains that contain 14 cysteines. The central region is a putative heparin...

The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study showed significant perinatal risks at levels of maternal hyperglycemia below values that are diagnostic for diabetes. A Consensus Panel of the International Association of Diabetes and Pregnancy Study Groups (IADPSG) reviewed HAPO Study results and other work that examined associations of maternal glycemia with perinatal and long-term...

Objective: Our aim in this study is to compare pregnancy and fetal outcomes following the diagnosis of gestational diabetes according HAPO/IADPSG, NICE criteria or when using both criteria. Methods: Diagnosis GDM was made lowest recommended cut off values HAPO/IADPSG guidelines were used management once diagnosed. The three groups compared, Group A: patients diagnosed any criteria, B: only from...

Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition during pregnancy. Women with GDM and their offspring have an increased risk of developing type 2 diabetes mellitus in the future. The global incidence of GDM is difficult to estimate, due to lack of uniform diagnostic criteria. Various diagnostic criteria have been proposed. The b...

We appreciate Ryan’s (1) thoughtful comments. The intent of our pooled analysis was to describe a normal pattern of glycemia in nonobese pregnant women according to the published data (2). We demonstrated that, similar to the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study (3), glucose concentrations in normal pregnancy are lower than were previously appreciated. If the treatment goal...

This practice guideline on gestational diabetes is a treatment oriented short version of the evidence based guideline that can be viewed in the internet. It replaces the DDG and DGGG recommendations of 2001 for diagnostic and therapy of gestational diabetes. A complete rework had become necessary in view of epidemiologically based diagnostic criteria, which had been derived from the Hyperglycae...

The HAPO Study Cooperative Research Group stated that the adverse perinatal outcomes were proportional to hyperglycemia in pregnancy [2]. Hyperglycemia results in complications like fetal hyperinsulinemia, birth trauma and macrosomia. These effects were translated into the adult life which increases the risk of obesity, metabolic syndromes and Type 2 diabetes [3]. Euglycemia ensures favourable ...

A s mentioned in the letter by SavonaVentura et al. (1), the results of fasting plasma glucose (FPG) screening protocol followed by an oral glucose tolerance test (OGTT) in the pregnant women whose FPG level was 4.4–5.0 mmol/L show a similar trend in the rate of missed diagnosis (12.2 vs. 10.1%) between our study (2) and their study (3), but substantially diverse rate in requiring a formal OGTT...