Front Cover: In article number 2000520 by Myungeun Seo, Wonhee Lee, and co-workers, a cross-coupling reaction is utilized for polymer surface modification. Poly(chloro-p-xylylene) (parylene C) used as substrate in Pd-catalyzed Buchwald–Hartwig amination to install primary amine groups. Parylene films with microscale topography can be successfully modified chemically bonded fabricate transparent...

Unusual 2,7-diazacarbazoles were prepared in one step from readily available tetra-halogenated 4,4'-bipyridines by using a double N-arylation reaction in the presence of the Pd-XPhos catalyst system. Moderate to good yields were obtained in this site-selective Buchwald-Hartwig double amination. The functionalization of these tricyclic derivatives was performed by using Pd-catalyzed cross-coupli...

Rapid development of the copper-catalyzed amination aryl halides in beginning 21st century, known as Renaissance Ullmann chemistry, laid foundations for use this method a powerful tool construction C(sp2)-N bond and became rival Buchwald–Hartwig reaction. Various applications approach are well-documented number comprehensive more specialized reviews, overview form personal account Cu-catalyzed ...

Pseudo-benzylic substitution is an important reaction in the ferrocene series, especially to obtain ligands for catalysis. Herein, we described new reactions conditions, using fluorinated alcohols as both solvent and promoter, able deliver iodoferrocene derivatives faster than classical solvents. Various N, O, P C-nucleophiles were found compatible with this transformation which occurs full ret...

Inspired by naturally occurring molecules containing atropisomeric N+-C axes, we have developed a novel synthetic approach to generate library of axially chiral N-aryl quinolinium salts. Enantiopurities up 93 % ee were obtained via four-step route from commercially available precursors. Axial stereochemistry was controlled through an enantioselective ring-closing Buchwald–Hartwig coupling react...

During thelast20-30 years, palladium-catalyzed reactions have witnessed tremendous advances in the industrial and organic reactions such as hydrogenation, coupling, cyanation and amination. Despite the wide utility of Pd-catalysts in these reactions, they suffer from a number of drawbacks such as recovery, reuse of catalyst and remain as  a contaminant in the products at the end of the reaction...

The synthetic route toward novel tricyclic, nitrogen-containing system is disclosed. Three compounds possessing structural features of 1,2,3,4-tetrahydroquinoxaline and decahydropyrido[3,4-b]pyrazine are synthesized starting from readily available precursors in six or seven steps, which the last three four steps respectively diastereoselective. Key reaction include N-acylation, Hofmann rearrang...

Using N-sulfonyl triazoles as substrates, compounds as diverse as 2-imino tetrahydrofurans, 13and 15membered ring aza-macrocycles can be prepared selectively via formal [1 + 4], [5 + 4 + 4] and [3 + 4 + 4 + 4] condensations of a-imino carbenes and oxetanes under Rh(II)-catalysis or thermal activation. Spirocyclic N-heterocycles are also accessible by means of Buchwald–Hartwig and Pictet–Spengle...

Several Hiyama cross-coupling reactions of oxasilacycloalkenes and aryl iodides are described that produce trisubstituted Z-styrenes in moderate to excellent yields. Both electron-rich and electron-poor aryl iodides are tolerated in the cross-coupling reaction. The oxasilacycloalkene coupling partners were prepared by ruthenium-catalyzed intramolecular anti-hydrosilylation of alkynols. One of t...

With localization techniques one can obtain general limit theorems for Toeplitz determinants with Fisher-Hartwig singularities from the asymptotics for any symbol with one singularity of general type. There exists a family of these for which the determinants can be evaluated explicitly and their asymptotics determined. But for the Wiener-Hopf analogue, although there are likely analogous locali...