نتایج جستجو برای: hbv rna
تعداد نتایج: 263726 فیلتر نتایج به سال:
background and aims: hdv is a defective satellite virus and classified in genus deltavirus. its disease is related and limited to hbv-infected patients. acute infection of delta agent occurs in two different patterns simultaneous infection with both hbv & hdv or super infection of chronically hbv infected patients that lead to more sever type of hepatitis. according to genetic diversity of geno...
The zinc finger antiviral protein (ZAP) is a mammalian host restriction factor that inhibits the replication of a variety of RNA viruses, including retroviruses, alphaviruses and filoviruses, through interaction with the ZAP-responsive elements (ZRE) in viral RNA, and recruiting the exosome to degrade RNA substrate. Hepatitis B virus (HBV) is a pararetrovirus that replicates its genomic DNA via...
UNLABELLED Chronic hepatitis B virus (HBV) infection is a major factor in hepatocellular carcinoma (HCC) pathogenesis by a mechanism not yet understood. Elucidating mechanisms of HBV-mediated hepatocarcinogenesis is needed to gain insights into classification and treatment of HCC. In HBV replicating cells, including virus-associated HCCs, suppressor of zeste 12 homolog (SUZ12), a core subunit o...
conclusions our study demonstrated that a low dose of rmp could inhibit hbv transcription and replication, which is dependent on the appearance of hbx in vivo. results rpb5-mediating protein could inhibit hbv transcription and replication in groups transfected with the 1.2 wt and hbx. the inhibitory effect disappeared in the 1.2x (-) groups, yet it reappeared in the groups co-transfected with 1...
Hepatitis B virus (HBV) and hepatitis delta virus (HDV) interplay was investigated by examining liver and serum samples from 21 coinfected and 22 HBV-monoinfected patients with chronic liver disease. Different real-time PCR assays were applied to evaluate intrahepatic amounts of HBV DNA, covalently closed circular DNA (cccDNA), pregenomic RNA (pgRNA), pre-S/S RNAs, and HDV RNA. Besides HBV DNA ...
Objective: To study the clinical value of hepatitis B virus pregenomic RNA (HBV-pgRNA) detection in treatment B. Methods: 60 patients with were included study. Serum HBV-pgRNA and HBV DNA levels different phases infection during detected, serum surface antigen (HbsAg) titer was detected by chemiluminescent immunoassay. extracted from liver biopsy tissue, covalently closed circular to predict th...
Aims: Healthy gut microbiome plays a crucial role in the treatment of Hepatitis B Virus (HBV) infection and chronic liver disease. Based on existing studies, we aimed to explore difference efficacy Fecal Microbiota Transplantation (FMT) patients with different stages HBV-related Methods: In this study, 10 HBV HBeAg-negative infection, 8 Chronic (CHB) hepatitis cirrhosis Child-Pugh score A, 9 B/...
Hepatitis B virus (HBV) is a small DNA virus with a compact genomic organization. All HBV proteins identified to date have been encoded by unspliced HBV RNAs. Spliced HBV RNAs have been described, but their functions are unknown. We show here that a singly spliced HBV RNA encodes a novel HBV protein in vivo. This HBV splice-generated protein (HBSP) corresponds to the fusion of a part of the vir...
Although PCR-based in situ hybridization (PCR-ISH) can be used to determine the distribution and localization of pathogens in tissues, this approach is hampered by its low specificity. Therefore, we used a highly specific and sensitive PCR-ISH method to reveal the lobular distribution and intracellular localization of hepatitis B virus (HBV) and HCV in chronic liver disease and to clarify the s...
Host innate recognition triggers key immune responses for viral elimination. The sensing mechanism of hepatitis B virus (HBV), a DNA virus, and the subsequent downstream signaling events remain to be fully clarified. Here we found that type III but not type I interferons are predominantly induced in human primary hepatocytes in response to HBV infection, through retinoic acid-inducible gene-I (...
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