Phospholipase A2 (PLA2) treatment has been shown previously to stimulate the sodium-dependent high-affinity choline uptake system as assessed by both the specific binding of [3H]hemicholinium-3 ([ 3H]HCh-3) and the uptake of [3H]choline. In the present study, the specificity of PLA2-induced stimulation upon [3H]HCh-3 binding has been examined. PLA2, as well as phospholipase C (PLC), treatment o...

A graph is clique-Helly if any family of mutually intersecting (maximal) cliques has non-empty intersection, and it is hereditary clique-Helly (abbreviated HCH) if its induced subgraphs are clique-Helly. The clique graph of a graph G is the intersection graph of its cliques, and G is self-clique if it is connected and isomorphic to its clique graph. We show that every HCH graph is an induced su...

The differential environmental fates and toxicities of the various hexachlorocyclohexane (HCH) isomers including lindane and isomers in the technical mixture will be the focus of this review. HCHs are one of the most widely used and most readily detected organochlorine pesticides in environmental samples. The relatively high volatility of HCH has led to global transport, even into formerly pris...

d-Hexachlorocyclohexane (d-HCH) interacts with cardiac ryanodine-sensitive Ca channels (RyR2), accounting in part for altered Ca transients and contractility (reported in companion report). Analysis of channel gating kinetics in the presence of d-HCH also revealed a nonfluctuating membrane current that remained even after RyR2 channels were blocked. We further elucidated the nature of a direct ...

Forty-five soil samples of surface (0–15 cm) and subsurface (15–30 cm) soils from agricultural sites of Delhi, Haryana, Haridwar, Uttar Pradesh (UP) and around the hexachlorocyclohexane (HCH) manufacturing plant of IPL (Indian Pesticide Limited) and nine samples of different commercial brands of drinking water from markets in Delhi were analysed for the presence of residues of HCH isomers. Thir...

Exposure to pesticides places pregnant women and the developing foetus at the highest risk. The objective of this study is to obtain an exposure assessment by investigating levels of pesticides in blood plasma of delivering women. We report on the concentrations of α, β, γ HCH, endosulfan, HCB and the pyrethroids: cis-permethrin, cyfluthrin, cypermethrin and deltamethrin found in the maternal b...

Novosphingobium lindaniclasticum LE124(T) is a hexachlorocyclohexane (HCH)-degrading bacterium isolated from a high-dosage-point HCH dumpsite (450 mg HCH/g soil) located in Lucknow, India (27°00'N and 81°09'E). Here, we present the annotated draft genome sequence of strain LE124(T), which has an estimated size of 4.86 Mb and is comprised of 4,566 coding sequences.

Pseudomonas aeruginosa MTB-1 does not degrade gamma-hexachlorocyclohexane (γ-HCH), but this bacterium persistently coexists with a γ-HCH-degrading strain, Sphingomonas sp. MM-1, in a microbial community enriched by the technical formulation of HCH. Here we report the complete MTB-1 genome sequence, with a 6.6-Mb circular chromosome.

El Diclorodifeniltricloroetano (DDT) y Hexaclorociclohexano (HCH) son disruptores endócrinos cuya presencia en la leche representa un riesgo para salud. Existe evidencia de que pasteurización disminuye o incrementa concentración plaguicidas organoclorados productos lácteos. La presente investigación evaluó el efecto a 63 °C 30 min-1 73 15 seg-1 las concentraciones DDT, HCH sus metabolitos bovin...