Single-walled carbon nanotubes (SWNTs) are promising candidates for a wide range of biomedical applications due to their fascinating properties. However, safety concerns are raised on their potential human toxicity and on the techniques that need to be used to assess such toxicity. Here, we integrate for the first time 3D tissue-mimetic models in the cytotoxicity assessment of purified (p-) and...

The Clonal Selection Algorithm is the most known algorithm inspired from the Artificial Immune Systems and used effectively in optimization problems. In this paper, this nature inspired algorithm is used in a hybrid scheme with other metaheuristic algorithms for successfully solving the Vehicle Routing Problem with Stochastic Demands (VRPSD). More precisely, for the solution of this problem, th...

1. Amantéa SL, Piva JP, Zanella MI, Bruno F, Garcia PC. Acesso rápido à via aérea. J Pediatr (Rio J). 2003;79 Suppl 2:S127-38. 2. The American Heart Association in Collaboration with the International Liaison Committee on Resuscitation. Guidelines 2000 for cardiopulmonary resuscitation and emergency cardiovascular care. Part 9: pediatric basic life support. Circulation. 2000;102 Suppl I:253-90....

1,-Glutamate is now well established as the predominant transmitter at fast-acting excitatory synapses in the mammalian central nervous system. Other amino acids such as L-aspartate and several acidic sulphur-containing amino acids (SAAs) which exhibit potent depolarizing actions similar to that of Lglutamate [I-31 are known to exist in the brain and/or are present in the brain under pathologic...

Morishita, Wade and Bradley E. Alger. Evidence for endogenous excitatory amino acids as mediators in DSI of GABAAergic transmission in hippocampal CA1. J. Neurophysiol. 82: 2556–2564, 1999. Depolarization-induced suppression of inhibition (DSI) is a process whereby brief ;1-s depolarization to the postsynaptic membrane of hippocampal CA1 pyramidal cells results in a transient suppression of GAB...

Morishita, Wade and Bradley E. Alger. Evidence for endogenous excitatory amino acids as mediators in DSI of GABAAergic transmission in hippocampal CA1. J. Neurophysiol. 82: 2556–2564, 1999. Depolarization-induced suppression of inhibition (DSI) is a process whereby brief ;1-s depolarization to the postsynaptic membrane of hippocampal CA1 pyramidal cells results in a transient suppression of GAB...

Submicron fibers of polyaniline (PAni) doped with (+)-camphor-10-sulfonic acid (HCSA) and blended with poly(methyl methacrylate) (PMMA) or poly(ethylene oxide) were electrospun over a range of compositions. Continuous, pure PAni fibers doped with HCSA were also produced by co-axial electrospinning and subsequent removal of the PMMA shell polymer. The electrical conductivities of both the fibers...

Aspergillus fumigatus is an opportunistic pathogen that causes 90% of invasive aspergillosis (IA) due to Aspergillus genus, with a 50-95% mortality rate. It has been postulated that certain virulence factors are characteristic of A. fumigatus, but the "non-classical" virulence factors seem to be highly variable. Overall, published studies have demonstrated that the virulence of this fungus is m...