Although the activation of the A(1)-subtype of the adenosine receptors (A(1)AR) is arrhythmogenic in the developing heart, little is known about the underlying downstream mechanisms. The aim of this study was to determine to what extent the transient receptor potential canonical (TRPC) channel 3, functioning as receptor-operated channel (ROC), contributes to the A(1)AR-induced conduction distur...

Background A cohort of 2181 men and women, aged 40 to 79 years, without evidence of coronary heart disease or cancer at entry to the Tecumseh Study was evaluated. Methods and Results Subjects were defined as lean if their Metropolitan Life Insurance table relative weight was <110 (n=584) and as obese if their relative weight was 2120 (n= 1024). There were 688 subjects with hypertension at study...

In heart muscle, strong evidence shows that excitation-contraction coupling involves Ca-induced Ca-release. However, under some conditions, single heart cells show Ca release and contraction which is not correlated with Ca entry via the Ca channel, suggesting a second Ca-independent release mechanism. Similar observations were made in early, pioneering studies using voltage-clamped multi-cellul...

A method of transseptal catheterization of the left side of the heart via the right subclavian vein has been described. It was attempted in 29 patients and the left atrium was entered in 26 patients. The left ventricle was entered in 2I of the 23 patients (9I%) where entry was attempted. The risks and advantages of this technique have been discussed. It is a useful additional method for cathete...

Background A cohort of 2181 men and women, aged 40 to 79 years, without evidence of coronary heart disease or cancer at entry to the Tecumseh Study was evaluated. Methods and Results Subjects were defined as lean if their Metropolitan Life Insurance table relative weight was <110 (n=584) and as obese if their relative weight was 2120 (n= 1024). There were 688 subjects with hypertension at study...

Cardiac arrhythmias are a frequent and important complication of cardiac failure regardless of aetiology. It might be expected that those afflicted would be aware of their occurrence, but surprisingly, even salvoes of ventricular tachycardia often are not perceived by patients. It has required 24 hour ambulatory electrocardiographic recordings to disclose the true prevalence of arrhythmias. The...

Heart rate increases are a fundamental adaptation to physiological stress, while inappropriate heart rate increases are resistant to current therapies. However, the metabolic mechanisms driving heart rate acceleration in cardiac pacemaker cells remain incompletely understood. The mitochondrial calcium uniporter (MCU) facilitates calcium entry into the mitochondrial matrix to stimulate metabolis...

The novel coronavirus infection, COVID-19, is a highly contagious viral disease associated with acute, severe respiratory syndrome, which based on the development of pronounced thrombo-inflammatory syndrome. As number patients COVID-19 increased, heart damage has been reported, especially in and critical COVID-19. This review describes role angiotensin-converting enzyme 2 receptor regulation en...