To cite: Sashikumar P, Gupta R, Conry B. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2013202059 DESCRIPTION Perinatal arterial ischaemic stroke (PAIS) is the cause for 10–15% of neonatal seizures and approximately 30% of childhood hemiplegia. We report a case of bilateral arterial stroke which initially was thought to be hemimegalencephaly and unilateral arter...

we report an unusual case of hemimegalencephaly (hmg) associated with ipsilateral congenital-infiltrating lipomatosis of the face in a five-month-old boy. hemimegalencephaly is a rare but unique malformation characterized by enlargement of all or parts of a cerebral hemisphere. the affected hemisphere may have focal or diffuse neuronal migration defects, with areas of polymicrogyria, pachygyria...

a Department of Neurology, University Hospital of Geneva, b Pediatric Neurology, Pediatric Specialties Service, Child and Adolescent Department, University Hospitals, Geneva, c Department of Neuroradiology, University Hospital of Geneva and University of Geneva, d Department of Neurosurgery, University Hospital of Geneva and Faculty of Medicine, University of Geneva, e Department of Neuropediat...

Neuronal migrational disorders of the brain represent abnormalities in the formation of the neocortex caused by faulty migration of the subependymal neuroblasts. These migrational anomalies include lissencephaly (agyria/pachygyria), pachygyria, schizencephaly, heterotopias, hemimegalencephaly, and polymicrogyria. We used MR imaging (performed on a 0.5-T or 1.5-T scanner) to evaluate 21 patients...

Investigators from Seattle Children's Research Institute, University of Washington, and collaborating institutions sought to evaluate 10 genes in the PI3K/AKT pathway as it relates epileptogenic brain malformations in patients with megalencephaly, hemimegalencephaly, and focal cortical dysplasia.

Isolated Hemimegalencephaly (iHME) is a rare form of congenital malformation of cortical development.It is characterized by enlargement of all or part of one cerebral hemisphere. It typically presents with intractable seizures, mental retardation, developmental delay, contralateral hemiparesis and hemianopia. The patient was a five and half month's old baby girl who presented first with focal s...