INTRODUCTION Preference for combination therapy to treat infection due to multidrug-resistant S. pneumoniae (MDRSP) has not been well elucidated in previous studies. METHODOLOGY In the present study, 19 antibiotics in combinations were tested against an MDRSP isolate. In vitro susceptibility studies including minimum inhibitory concentration (MIC), minimal bactericidal concentrations (MBC) an...

In this study, 468 Listeria strains were checked for the presence of phosphatidylinositol-specific phospholipase C (PI-PLC) activity by using a simple assay that consisted of overlaying colonies formed on agar plates with L-alpha-phosphatidylinositol as substrate. In this assay, PI-PLC-active colonies show turbid halos around the colonies as a result of the release of insoluble diacylglycerol f...

Objective(s):Gemifloxacin is a broad spectrum antibiotic and has shown excellent coverage against a wide variety of microorganisms. In this study, an attempt was made to evaluate the immunomodulatory potential of gemifloxacin in male swiss albino mice in vivo. Materials and Methods: Three doses of gemifloxacin 25 mg/kg, 50 mg/kg and 75 mg/kg were used intraperitoneally (IP) for the evaluation ...

A chance discovery of the tumoricidal action of a human milk fraction led to the characterization of the active component as oleic acid complex of the α-lactalbumin, which was given the acronym HAMLET. We report in this study that the oleic acid complex of bovine α-lactalbumin (BAMLET) is hemolytic to human erythrocytes as well as to those derived from some other mammals. Indirect immunofluores...

In the present study, the peptides secreted by the dorsal skin of Rana tigrina have been isolated and its effects on cellular and humoral immunity has been studied in normal and tumor bearing mice. To evaluate the role of the peptide in cellular immunity delayed type hypersensitivity (DTH) response has been assayed in normal and DL (Dalton’s lymphoma) bearing mice and the effect of the skin pep...

Vibrio alginolyticus has been associated with several diseases of cultivated marine animals, and has led to considerable economic losses. The oligopeptide permease (Opp) has been proven to play a variety of important roles in nutrition and virulence in several bacteria. In our previous research, the opp gene cluster was identified in Vibrio alginolyticus with transcriptome sequence, which also ...

Zerumbone is a well-known compound having anti-cancer, anti-ulcer, anti-inflammatory and anti-hyperglycemic effects. During its use for the disease treatment, membrane of erythrocyte can be affected by consumption this bioactive compound. The current study was first report investigation hemolytic activities on human erythrocytes cytotoxic profile zerumbone. toxicity zerumbone determined in vitr...

A variant of glucose-6-phosphate dehydrovariant is the slowest yet described. genase (G-6-PD) designated G-6-PD Substrate specificity is normal but enzyme Manchester, and associated with chronic activity is markedly inhibited by NADPH, nonspherocytic hemolytic anemia. was and this is thought to account for the severe found in an English male. The electrochronic hemolysis. phoretic mobility at p...

background and purpose: gastric cancer (gc) is one of the most common cancers worldwide and in iran. as conventional therapies such as surgery and chemotherapy are invasive with adverse effects, current studies are important as they are conducted to find natural compounds with few adverse effects. in this study, melittin with 26 amino acids was isolated and purified from bee venom and its effec...