Hepatic disease is usual in large animals. Increases in serum hepatic enzymes and total bile acid concentration may indicate hepatic dysfunction, insult, disease, or failure. While liver disease is particularlyusual in foals, progression to liver failure isn't.Diseases that frequently result in hepatic failure in horses include Theiler's disease, Tyzzer's disease, pyrrolizidine alkaloid toxicos...

The authors prepared D-galactosamine (Gal) hepatic failure rats and hepatic failure dogs induced by hepatic ischemia and studied the correlation between the progress of hepatic failure and amount of trace metal in liver measured of the rats and dogs. After Gal was given, the rats rapidly fell into hepatic failure condition. They were sacrificed with the lapse of time and their zinc (Zn) content...

A reproducible animal model of fulminant hepatic failure was developed by intraperitoneal administration of D-galactosamine hydrochloride to Sprague-Dawley rats. Biochemical and morphological hepatic injury and brain edema resembled human fulminant hepatic failure. This model would facilitate further studies of the pathogenesis of brain dysfunction and evaluation of treatment in fulminant hepat...

Fulminant hepatic failure' is defined as severe, acute impairment of hepatic function culminating in hepatic encephalopathy, the encephalopathy being the result of hepatocellular failure and supervening within three weeks of the onset of symptoms*. This definition excludes the hepatic encephalopathy of hepatic cirrhosis and of chronic hepatitis, which produces a slightly different clinical pict...

Although the incidence of fulminant hepatic failure appears to have decreased worldwide, the management of this dreaded condition remains unsatisfactory (1). Despite ingenious methods of treatment, the mortality in patients with grade IV coma is still between 80 and 90% in most major series (15, 20). Furthermore the mortality is nearly 100% in patients ov~r the age of 45 who develop grade IV co...

introduction: indian childhood cirrhosis is a chronic liver disease usually seen in paediatric age group and is unique to the indian subcontinent. the definitive causative factor for the disease is not found till now but excess copper ingestion has been associated with it.case presentation: an indian origin one and half year old premorbidly normal male child presented with history of gradual di...

Hepatic hemangioendothelioma is rare. We report on hepatic hemangioendotheliomas in 2 young infants, with initial manifestations of respiratory distress and congestive heart failure. Serum alpha-fetoprotein (alphaFP) level was as high as 26,343 microg/l at 14 days old in 1 case, but was only 18 microg/l in the other case. The 2 patients were treated with prednisolone and hepatic artery ligation...