(1) Aim of the Study: In this study, we aimed to evaluate vascular damage and effects nitric oxide synthase (NOS) enzyme inhibitors in hepatic caused by high doses acetaminophen (APAP). (2) Material methods: Fifty-three Swiss albino male mice were used for study. Hepatic thoracic aorta toxicity 2 or 6 h exposures APAP (300 mg/kg intraperitoneally (i.p.)) evaluated. The general NOS inhibitor NG-...

objective(s):  protective effects of different extracts and essential oil from pimpinella anisum           l. seeds were examined against carbon tetrachloride (ccl4)-induced toxicity. the parameters such as serum transaminases, lactate dehydrogenase activity, hepatic glutathione content, liver lipid peroxidation and histopathological changes of liver were assessed as toxicity markers. in the in...

Objective(s):  Protective effects of different extracts and essential oil from Pimpinella anisum           L. seeds were examined against carbon tetrachloride (CCl4)-induced toxicity. The parameters such as serum transaminases, lactate dehydrogenase activity, hepatic glutathione content, liver lipid peroxidation and histopathological changes of liver were assessed as toxicity markers. In the in...

background: bone marrow transplantation is a good therapeutic modality for beta thalassemia. liver complications is one of the major causes of morbidity and mortality following bmt. determination of the factors of liver injury leads to earlier diagnosis after bmt and improves prognosis. materials and methods: we studied 113 major beta thalassemic patients who have been transplanted from 1990- 2...

Daphniphyllum calycinum (DC), a main component of Chinese patent drug Fengliao-Changweikang, is effectively used to cure bowel disease in the clinic. It was recorded that DC possessed slight toxicity, which was caused by the alkaloids existing in its extract. Unfortunately, to date the toxicity level and toxic constituents are still unclear. The present study is designed to illustrate the acute...

Although continuous hepatic artery infusions (CHAI) of (FUDR) Floxuridine have been effective in reducing the size of colorectal hepatic metastases the toxicity of the infusions have been high with almost a quarter of the patients developing biliary sclerosis. Techniques to lower toxicity, yet continue the beneficial antitumor effects, are being investigated. One suggested strategy is to change...

OBJECTIVE To compare the relative hazard of muscle toxicity, renal dysfunction, and hepatic dysfunction associated with the drug interaction between statins and concomitant medications that inhibit the CYP3A4 isoenzyme. BACKGROUND Although statins provide important clinical benefits related to mitigating the risk of cardiovascular events, this class of medications also has the potential for s...

Hepatic copper accumulation is a regular feature of primary biliary cirrhosis (PBC). The levels are directly related to the clinical stage of the disease. Since the copper values in PBC are comparable to Wilson's disease, there is the potential for copper toxicity, although this is speculative since the two diseases differ in the binding, distribution, and intracellular localization of the copp...

26 1. Method and Search Strategy 28 2. Chloroquine 29 2.1 Mild and Moderate Adverse Effects 29 2.2 Severe Adverse Effects 30 2.3 Overdose Toxicity 30 2.4 Use in Pregnant Women 31 2.5 Use in Breast-Feeding Women 31 2.6 Contraindications and Cautions 31 3. Suifadoxine/Pyrimethamine 31 3.1 Miid and Moderate Adverse Effects 32 3.2 Severe Adverse Effects 32 3.2.1 Cutaneous Toxicity 32 3.2.2 Hepatic ...