Three urea cycle enzymes, argininosuccinate synthetase, argininosuccinate lyase, and argÃ1⁄4Ã-ase, and two amino acyl-RNA synthetases, the glutamyl and the glutaminyl enzymes, have been studied in the Novikoff hepatoma and Morris Hepatomas 7787, 7793, and 7800. Except for Hepatoma 7793, which had "normal" activities of the 3 urea cycle enzymes, other hepatomas had lower activities than normal l...

Three urea cycle enzymes, argininosuccinate synthetase, argininosuccinate lyase, and argÃ1⁄4Ã-ase, and two amino acyl-RNA synthetases, the glutamyl and the glutaminyl enzymes, have been studied in the Novikoff hepatoma and Morris Hepatomas 7787, 7793, and 7800. Except for Hepatoma 7793, which had "normal" activities of the 3 urea cycle enzymes, other hepatomas had lower activities than normal l...

The leukocyte migration inhibition assay was used to detect cell-mediated immune reaction of hepatoma patients. Extraction of 3 pairs of human hepatoma tissue and normal liver tissue was made by 3 M KCI solution, and soluble hepatoma antigens were used to test against leukocytes of 18 hepatoma patients by the leukocyte migration inhibition assay. In all, 25 tests were performed; most of them we...

Purpose: To investigate the effect of excisanin A on human hepatocellular carcinoma cells as well to elucidate its mechanism action.
 Methods: Molecular docking was used determine binding characteristics HIF-1α protein. The transcriptional activation and viability were assessed using Luciferase reporter MTT assay. protein in nucleus assayed western blot immunofluorescence. VEGF mRNA levels...

A rational comparison of different serum concentrations of alpha1-fetoprotein (S-AFP) in the diagnosis of hepatoma must be made. We took data on the sensitivity and specificity of different diagnostic S-AFP concentrations from the literature and evaluated them statistically and by Bayesian analysis. In our patients (hepatoma prevalence 0.028) a sensitive diagnostic concentration (30-50 ng/ml) w...

Hepatoma cells derived from liver carcinoma are a candidate cell source for bioartificial (BAL) systems due to their high proliferative capacity, although function of hepatoma is considerably low compared with primary hepatocytes. In our previous study, genetically engineered mouse inducible were established by transducing liver-enriched transcription factor (LETF) genes. this we aimed develop ...

Carnosic acid (CA), carnosol (CL) and rosmarinic (RA), components of the herb rosemary, reportedly exert favorable metabolic actions. This study showed that both CA CL, but not RA, induce significant phosphorylation AMP-dependent kinase (AMPK) its downstream acetyl-CoA carboxylase 1 (ACC1) in HepG2 hepatoma cells. Glucose-6-phosphatase (G6PC) phosphoenolpyruvate carboxykinase (PCK1), rate-limit...

Sesquiterpenoid tagitinin C, present in Tithonia diversifolia leaves, has been known to have anti-hepatoma properties. Therefore, we investigated the anti-metastatic potential of C xenograft models hepatocellular carcinoma (HCC). We isolated from a methanolic extract leaves T. diversifolia. HepG-2 and Huh 7 hepatoma cells were treated with cell viability, migration, matrix metalloproteinase (MP...

To explore the effect of esomeprazole on biological characteristics hepatoma cells by regulating protein kinase B/forkhead box O3 pathway. Hepatoma cell lines were cultured and subcultured divided into model group, low dose group high group. The changes proliferation, colony formation apoptosis in each expression levels related proteins pathway detected. Esomeprazole inhibited tumor a time dose...