C disseminated candidiasis or Hepatosplenic candidiasis (HSC) is a rare and potentially morbid and mortal complication encountered in febrile neutropenic patients. It is generally associated with recovery from neutropenia, and may occur after the treatment of an episode of acute hematogenous candidiasis. Clinical signs and symptoms include fever unresponsive to antibiotics, abdominal pain and t...

1. Michailov G, Laporte JPH, Lesage S, et al. Autologous bone marrow transplantation is feasible in patients with a prior history of invasive pulmonary aspergillosis. Bone Marrow Transplant 1996; 17:569-72. 2. Martino R, Lopez R, Sureda A, Brunet S, Domingo Albos A. Risk of reactivation of a recent invasive fungal infection in patients with hematological malignancies undergoing further intensiv...

Blood samples were drawn daily from 72 patients who had hematological malignancies, neutropenia, and fever and who had failed to respond to broad-spectrum antibiotics. Each sample was used for conventional fungal blood cultures and for detection and identification of Candida DNA by a PCR method with subsequent restriction enzyme analysis (REA) recently developed in our laboratory. The PCR metho...

The aim of the study is to assess the clinical spectrum of immunorestitution disease (IRD) in hospitalised patients over a 12-month period. In 9 of 18 patients who presented with clinical deterioration during reduction or cessation of immunosuppressants (n=6) or bone marrow engraftment (n=3), IRD cases included scabies infestation (n=1), gastric strongyloidiasis (n=1), hepatosplenic candidiasis...

Candida infections are the most frequent infections in neutropenic patients. Hepatosplenic candidiasis (HSC) is a part of disseminated Candida infection that occurs most commonly in patients with hematologic malignancies treated with chemotherapy and requires protracted antifungal therapy. During invasive mycosis with rapid resolution of immunosuppression, immune reconstitution inflammatory syn...

INTRODUCTION Patients with a history of chemotherapy or stem cell transplantation (SCT) and prolonged neutropenia are at risk for hepatic and/or splenic seeding of Candida. In our experience, hepatosplenic candidiasis (HSC) without documented candidemia often remains unrecognized. CASE PRESENTATIONS We describe three cases of HSC without documented candidemia and the challenges in establishin...