نتایج جستجو برای: hepsin
تعداد نتایج: 119 فیلتر نتایج به سال:
Hepsin is a type II transmembrane serine protease that is expressed in normal liver, and at lower levels in kidney, pancreas, and testis. Several studies have shown that hepsin mRNA is significantly elevated in most prostate tumors, as well as a significant fraction of ovarian and renal cell carcinomas and hepatomas. Although the overexpression of mRNA in these tumors has been extensively docum...
Currently, several therapeutic approaches including surgery, chemotherapy, and radiation therapy are available for the treatment of endometrial cancer. However, endometrial cancer cells may survive, resulting in relapse of the disease, and ultimately causing demise of the patient. Hepsin is a cell surface-expressed chymotrypsin-like serine protease and a member of the family of type II transmem...
If treated early, prostate cancer is usually curable. After metastasis occurs, however, these tumors become resistant to treatment and are generally fatal. Therefore, inhibiting metastasis may significantly improve the survival time for patients with prostate cancer. The Vasioukhin laboratory has previously shown that the host serine protease Hepsin promotes prostate cancer progression and meta...
Prostate cancer is the most commonly diagnosed noncutaneous cancer in men. Despite this fact, many of the genetic changes that coincide with prostate cancer progression remain enigmatic. We have addressed this problem by characterizing the expression profiles of several benign and malignant human prostate samples, and we have identified several genes that are differentially expressed between be...
Prostate cancer is the most commonly diagnosed noncutaneous cancer in men. Despite this fact, many of the genetic changes that coincide with prostate cancer progression remain enigmatic. We have addressed this problem by characterizing the expression profiles of several benign and malignant human prostate samples, and we have identified several genes that are differentially expressed between be...
Uromodulin is the most abundant protein in the urine. It is exclusively produced by renal epithelial cells and it plays key roles in kidney function and disease. Uromodulin mainly exerts its function as an extracellular matrix whose assembly depends on a conserved, specific proteolytic cleavage leading to conformational activation of a Zona Pellucida (ZP) polymerisation domain. Through a compre...
Abstract Ras proteins play a causal role in human cancer by activating multiple pathways that promote growth and invasion. However, little is known about how induces the first diagnostic features of invasion solid tumors, including loss epithelial integrity breaching basement membrane (BM). In this study, we found oncogenic strongly promotes activation hepsin, member hepsin/TMPRSS type II trans...
Background: Hepsin, a type II transmembrane serine protease encoded by HPN gene, is commonly overexpressed in prostate and breast cancer. Hepsin protein stabilized Ras-MAPK pathway signaling, downstream, this regulates the degradation of extracellular matrix components activates growth factor pathways, including hepatocyte transforming (TGF) beta pathway. The significance hepsin-dependent signa...
Pericellular proteolytic activity affects many aspects of cellular behaviour, via mechanisms involving processing of the extracellular matrix, growth factors and receptors. The serine proteases have exquisitely sensitive regulatory mechanisms in this setting, involving both receptor-bound and transmembrane proteases. Receptor-bound proteases are exemplified by the uPA (urokinase plasminogen act...
We report the identification and characterization of mouse matriptase-2 (m-matriptase-2), an 811-amino-acid protein composed of an N-terminal cytoplasmic domain, a membrane-spanning domain, two CUB (complement protein subcomponents C1r/C1s, urchin embryonic growth factor and bone morphogenetic protein 1) domains, three LDLR (low-density-lipoprotein receptor class A) domains and a C-terminal ser...
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