We compared fluorescence in situ hybridization (FISH), immunohistochemical analysis, immunocytochemical analysis, and relative quantification assays using polymerase chain reaction (PCR) as methods for estimating HER-2 gene amplification and protein overexpression in fine-needle aspirate (FNA) specimens and paraffin-embedded tissue samples from 49 cases of breast cancer. FISH can be performed s...

We report here a 44-year-old Moroccan man with resectable gastric adenocarcinoma with overexpression of human epidermal growth factor receptor 2 (HER2) by immunohistochemistry who was treated with trastuzumab in combination with chemotherapy in perioperative setting. He received 3 cycles of neoadjuvant chemotherapy consisting of trastuzumab, oxaliplatin, and capecitabine. Afterwards, he receive...

Introduction: Ovarian Cancers account for the greatest number of deaths from malignancies female genital tract and it is fifth leading cause cancer fatalities in women. Surface epithelial tumours are most common, followed by germ cell tumours. Objective: To analyse expression EGFR HER 2neu using Immunohistochemisty different with special reference to surface Epithelial Material Methods: 52 case...

S'Ve PictS Neuter tells her story in simple yet arresting language, giving a very comprehensive des UI~k man ̂ euter> who was her teacher, her colleague, and finally her husband. Po\ver Qp ? .^'m as an extraordinarily dynamic person, with an unshakable belief in the Hany 0r sP'r'1 over matter. His enthusiasm attracted large numbers of people to him, ^ey?te th ? ^ were prepared to withstand the t...

This paper investigates how professional workers’ willingness to act with interpersonal sensitivity is influenced by the gender and power of their interaction partners. We call into question the idea that mixed-gender interactions involve more interpersonal sensitivity than all-male interactions primarily because women demonstrate more interpersonal sensitivity than do men. Rather, we argue tha...

Background:Breast cancer remains the most common and second lethal cancer in females. HER-2/neu is one of the most important amplified oncogene in breast cancer. The amplification of HER-2 is correlated with decreased survival, metastasis, and early recurrence.  The amplification of HER-2/neu gene and synthesis of th...

Background: In the present study, we aimed to determine expression of PDL1 and its correlation with TIL in Triple Negative (ER, PR Her 2neu negative) cases breast carcinoma (immune-histochemical study) 
 Methods: Expression PD-L1 was seen on 40 proven triple negative carcinomas (TNBC) correlate it other parameters affecting prognosis disease. All were infiltrating ductal NOS (not otherwise...

Background & objective: The HER-2 gene is an important on co protein overexpressed in many types of cancers. The current study hypothesized that curcumin downregulates HER-2 and inhibits the signal transduction pathway of PI3K/Akt, MAPK, and activation of NFκB, which could be useful to treat overexpressed-HER-2 hepatocellular carcinom...

background: it has been previously demonstrated that her-2 (human epidermal growth factor receptor 2) positive breast cancers are associated with an aggressive nature. villin is an actin bundling protein that plays a key role in actin reorganization and cell remodeling during stress. in this study, we aimed to investigate the correlation of villin gene expression with her-2 in breast cancer pat...