Metabolism and transport from intestinal cells back into the lumen by ATP-binding cassette (ABC) transporters is believed to limit the bioavailability of flavonoids. We studied metabolism and transport of the citrus flavonoid hesperetin, the aglycone of hesperidin, using a two-compartment transwell Caco-2 cell monolayer system, simulating the intestinal barrier. The role of apically located ABC...

BACKGROUND High plasma concentration of low-density lipoprotein cholesterol (LDL-c) plays a significant role in the incidence of atherosclerosis and coronary heart diseases. The aim of this study was to investigate the mechanism by which the citrus flavonoid, hesperetin, regulates the LDL receptor (LDLr) gene in the human liver using the human hepatoma cell line, HepG2. METHODS Luciferase rep...

Background and objectives: Hesperetin (Hst), aglycone form of hesperidin, is reported to have antioxidant, anti-inflammatory and neuroprotective activities. On the other hand, the latest nanoparticle technology can help to improve the bioavailability of Hst, which is affected by the final particle size and stability. Alzheimer’s disease is a neurodegenerative disease, character...

Some blood orange juice (BOJ) flavanones may have antioxidant, anti-inflammatory, anti-allergic, hypolipidaemic, vasoprotective and anticarcinogenic properties. The aim of the present study was to evaluate the pharmacokinetics of hesperetin and naringenin in human subjects after BOJ intake. In a cross-over study, seven healthy female volunteers consumed 150 and 300 ml BOJ corresponding to about...

BACKGROUND The re-emerging, Aedes spp. transmitted Chikungunya virus (CHIKV) has recently caused large outbreaks in a wide geographical distribution of the world including countries in Europe and America. Though fatalities associated with this self-remitting disease were rarely reported, quality of patients' lives have been severely diminished by polyarthralgia recurrence. Neither effective ant...

abstractparkinson’s disease (pd) is a neuropathological and debilitating disorder involving the degeneration of mesencephalic dopaminergic neurons. neuroprotective effect of hesperetin has already been reported, therefore, this study examined whether the administration of this flavonoid would attenuate behavioral abnormalities in an experimental model of pd in rat. for this purpose, unilateral ...

Multiple sclerosis (MS) is one of the most autoimmune neurological and inflammatory disease in worldwide. Demyelination and disturbance of action potential conductance are regarded as main signs of MS disease. Hesperetin (Hst) is one of the flavonoid that have neuroprotective properties. The present study attempts to evaluate the effects of hesperetin or its nanoparticle on myelin repair and gl...

objective: this study was designed to investigate the antinociceptive effect of chronic administration of the flavonoid hesperetin in streptozotocin-diabetic rats using formalin and hot tail immersion tests. materials and methods: rats were divided into 5 control groups, hesperetin-treated control, diabetic, sodium salicylate (ss)-treated diabetic, and hesperetin- and glibenclamide-treated dia...

The aim of this study was to examine in vitro, by means of kinetic analysis and molecular docking simulations, the effects of the flavone diosmetin and its flavanone analog hesperetin on CYP (cytochrome P450) 2C9-mediated drug metabolism. To this purpose, the conversion of diclofenac to 4'-hydroxydiclofenac by human liver microsomes was used as a model assay for assessing the CYP2C9 inhibitory ...

Diabetes is a life-long disease and is considered as the second foremost reason to cause blindness and renal failure worldwide. It is a chronic disease caused by inherited or acquired deficiency in the production of insulin by the pancreas, or by ineffectiveness of the secreted insulin. This study is carried out to evaluate the effect of hesperetin on dearrangement in glycoprotein levels in the...