In vitro digestion of marine oils has been reported to promote lipid oxidation, including the formation of reactive aldehydes (e.g., malondialdehyde (MDA) and 4-hydroxy-2-hexenal (HHE)). We aimed to investigate if human in vitro digestion of supplemental levels of oils from algae, cod liver, and krill, in addition to pure MDA and HHE, affect intestinal Caco-2 cell survival and oxidative stress....

PURPOSE To determine whether hyperpolarized helium-3 (HHe) diffusion MR can detect the expected enlargement of alveoli that occurs with lung growth during childhood. MATERIALS AND METHODS A total of 29 normal subjects aged four to 30 years underwent HHe diffusion MR imaging with the b-value pair 0, 1.6 second/cm(2). A second acquisition during a separate breathhold was performed using the b-v...

Hypotonic-hyporesponsive episode (HHE), sometimes called the ragdoll, collapse reaction, or shock-like state refers to an adverse event occurring after administration of whole-cell pertussis vaccine; the infant becomes pale and displays decreased responsiveness, muscle tone, and activity. Although HHE occurs most often after immunization with whole-cell pertussis vaccine, it has also been repor...

BACKGROUND Oxidized low-density lipoprotein (oxLDL) promotes apoptosis in atherosclerotic plaques in the vascular wall, a process mediated through its oxidized lipids. 4-Hydroxynonenal (HNE) and 4-hydroxyhexenal (HHE), derived from oxidation of n-6 and n-3 fatty acids, respectively, are among the major oxidized products in oxLDL. HYPOTHESIS This study hypothesized that eicosapentaenoic acid/d...

The volatile nature of the SRAM ce l l s that hold configuration state in most current reconfigurable logic devices is a significant limitation, requiring that the device be re-programmed each t ime power is applied. In this paper, w e present a new class of reconfigurable logic elements based on magnetoelectronic devices, known as hybrid Hall effect (HHE) devices. HHE devices can be configured...

Lipid peroxidation yields multiple aldehyde species. Of these, trans-4-hydroxy-2-nonenal (HNE), derived from n-6 poly-unsaturated fatty acids (PUFA) is one of the most studied products of lipid peroxidation. On the other hand, oxidative damage to n-3 PUFA, e.g. docosahexaenoic acid (DHA; 22:6, n-3) and eicosapentaenoic acid, is now recognized as an important effector of oxidative stress and is ...

STUDY OBJECTIVES To compare the diagnostic capability of recently available hand-held echocardiography (HHE) and of conventional transthoracic echocardiography (TTE) used as a gold standard in critically ill patients under mechanical ventilation. DESIGN A prospective and descriptive study. SETTING The general intensive care unit of a teaching hospital. PATIENTS All mechanically ventilated...

Background—Evidence on economically efficient strategies to lower blood pressure (BP) from lowand middle-income countries remains scarce. The Control of Blood Pressure and Risk Attenuation (COBRA) trial randomized 1341 hypertensive subjects in 12 randomly selected communities in Karachi, Pakistan, to 3 intervention programs: (1) combined home health education (HHE) plus trained general practiti...

BACKGROUND Evidence on economically efficient strategies to lower blood pressure (BP) from low- and middle-income countries remains scarce. The Control of Blood Pressure and Risk Attenuation (COBRA) trial randomized 1341 hypertensive subjects in 12 randomly selected communities in Karachi, Pakistan, to 3 intervention programs: (1) combined home health education (HHE) plus trained general practi...

A recent report indicated that hyperhomocysteinemia (Hhe), in addition to its atherothrombotic effects, exacerbates the adverse cardiac remodeling seen in response to hypertension, a powerful stimulus for pathological ventricular hypertrophy. The present study was undertaken to determine whether Hhe has a direct effect on ventricular remodeling and function in the absence of other hypertrophic ...