Background-Patients with cancer have long periods of severe neutropenia due to chemotherapy and are particularly vulnerable to infectious complications. Most fever episodes are treated with empiric antibacterial therapy without identifying the etiologic agent. Blood culture is the gold standard test to detect infections, but it usually presents negative results. Human herpes virus establishes l...

Histiocytic necrotizing lymphadenitis (HNL) usually affects cervical lymph nodes of young individuals and has a self-limited clinical course. Viral infection is ascribed as its cause, but its pathogenesis still remains unknown. A real-time PCR assay is useful for not only sensitive detection but also quantitation of virus DNA with a wide linear range. Using this technology, we estimated the loa...

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Acute lymphoblastic leukemia (ALL) is the most common cancer during childhood. Nevertheless, in recent years there have been marked improvements in treatment and consequent survival....

A symposium to celebrate the life and work of Dr. Caroline Breese Hall (or Caren as she was known to thousands of her colleagues, students, mentees, and friends) was held at the University of Rochester School of Medicine & Dentistry on April 25, 2014. The symposium also served as an opening event to announce the establishment of the Caroline Breese Hall, MD Endowment for Infectious Diseases at ...

Received 15 May 2007; accepted 15 May 2007; electronically published 1 October 2007. Potential conflicts of interest: P.E.P. receives royalties for sales of a reagent that can be used to diagnose HHV-6 infections. J.G. declares no potential conflicts. Financial support: Cleveland Clinic. Reprints or correspondence: Dr. Philip E. Pellett, Cleveland Clinic, 9500 Euclid Ave., NN10, Cleveland, OH 4...