English abstractInternet-mediated research methods are increasingly used to access hidden crime-involved populations such as drug users and dealers. Based on an online survey study of over 800 individuals engaged in illegal small-scale cannabis cultivation Denmark, this article focuses the recruitment allegedly »hidden« population. In article, we critically reflect about concepts »hidden-« »har...

TEM β-lactamase confers bacteria with resistance to many antibiotics and rapidly evolves activity against new drugs. However, functional changes are not easily explained by differences in crystal structures. We employ Markov state models to identify hidden conformations and explore their role in determining TEM's specificity. We integrate these models with existing drug-design tools to create a...

Estimates of population size for hidden and hard-to-reach individuals are of particular interest to health officials when health problems are concentrated in such populations. Efforts to derive these estimates are often frustrated by a range of factors including social stigma or an association with illegal activities that ordinarily preclude conventional survey strategies. This paper builds on ...

BACKGROUND Efforts have focused on developing innovative recruitment strategies to engage the most marginalized of populations in public health research. Respondent-driven sampling (RDS) has been found to be an effective sampling strategy for hard-to-reach, hidden populations. Though studies have documented RDS peer referral as challenging, literature contextualizing these challenges is scant a...