Experimental work was carried out to investigate the influence of impeller speed, granulation time, binder mass and their interactions on granule size distribution, mean size and binder content distribution in a conical high shear granulator. It was observed that the response of high shear granulation to changes in process parameters varies significantly from one operating condition to anot...

Not Yet Available Detecting and Measuring Nucleation in High Shear Granulation M. Oullion , G.K. Reynolds 2 and M.J. Hounslow 1 Session 4: High Shear Processes 2 23 1) University of Sheffield, UK 2) AstraZeneca, UK Particulate processes are of great importance in industries like chemical, agricultural or pharmaceutical industries [1]. High-shear granulation is commonly part of the solid product...

We present a new design for a confocal rheoscope that enables uniform uniaxial or biaxial shear. The design consists of two precisely positioned parallel plates with a gap that can be adjusted down to 2 ±0.1 μm, allowing for the exploration of confinement effects. By using our shear cell in conjunction with a biaxial force measurement device and a high-speed confocal microscope, we are able to ...

By E. Janiaud AND F. Graner † 1 Laboratoire des Milieux Désordonnés et Hétérogènes, case 78, Université Paris 6 and CNRS UMR 7603, 140 rue de Lourmel, 75015 Paris, France. 2 Université Paris 7, Denis Diderot, Fédération de Recherche FR2438 Matière et Systèmes Complexes, 2 place Jussieu, 75251 Paris Cedex 05, France. 3 Laboratoire de Spectrométrie Physique, CNRS UMR 5588 et Université Grenoble I...

Model-driven design requires a well-calibrated model and therefore needs efficient workflows to achieve this. This efficiency can be achieved with the identification of critical process parameters (CPPs) most impactful modelling followed by targeted experimental campaign prioritise calibration these. To identify these it is essential perform global sensitivity analysis (GSA). Here, an GSA appli...

Aerobic granulation is a promising biotechnology for wastewater treatment. The formation and development of granules and the pollutant removal are closely associated with hydrodynamic shear force, settling time and volume exchange ratio (VER), which are proved to be the selection pressures. Three different values of shear force (2, 3 and 4 cm/s), settling time (3, 5 and 10 min) and VER (25, 50 ...

We review recent developments in the field of microrheometry and describe a new flexure-based microrheometer (FMR) that can make measurements of the steady shear viscosity of transparent or optically-opaque complex fluids using 1-10 μl samples. We document the complex microrheology that may arise in a typical consumer product such as a skin crème, when the microstructure of the multiphase mater...