• Orai1 was suggested to amplify dendritic spine Ca 2+ signals. However, Orai2 more abundant than in spines of hippocampal neurons. Roles and Orai3 neurons were not addressed. The contribution IP 3 -dependent release considered. channels reported as critical contributors the signal underlying synaptic plasticity associated with learning memory. We discuss results view conflicting other reports ...

neurogenesis occurs throughout life in several regions of the brain. in this lecture, a new sight for the role of the dentate gyrus and adult hippocampal neurogenesis in anxiety disorders will be discussed. the region that has obtained the most attention for its involvement in the neurogenesis of affective and anxiety disorders are the hippocampal and dentate gyrus. evidence strongly suggests t...

The cover image is based on the Editorial Hippocampal system neurons encoding views in different species: Introduction to Special Issue of Hippocampus 2023 by Edmund T. Rolls and Sylvia Wirth https://doi.org/10.1002/hipo.23538.

Glutamate induces excitotoxic damage to hippocampal pyramidal neurons in Status Epilepticus (SE) and epilepsy. In this study, we investigated time course of dysregulation of calcium homeostasis at various intervals after an episode of SE in acutely isolated CA1hippocampal pyramidal. For this purpose, male Sprague-Dawley rats (200 g) were subjected to pilocarpine-induced SE. The SE was blocked a...

Introduction: Alzheimer disease (AD) is the most common form of dementia in the elderly that slowly destroys memory and cognitive functions. The disease has no cure and leads to significant structural and functional brain abnormalities. To facilitate the treatment of this disease, we aimed to investigate proline-rich peptide (PRP-1) action of hypothalamus on hippocampal (HP) neurons and dynamic...

Introduction: Antibiotic supplements are regularly used in neuronal culture media to control contamination however, they can interfere with the neuronal excitability and affect electrophysiological properties. Therefore, in this study, the effect of penicillin/streptomycin supplements on the spontaneous electrophysiological activity of hippocampal pyramidal neurons was examined. Methods: Electr...

Neuropsychiatric lupus (NPSLE), a manifestation of the autoimmune disease systemic erythematosus (SLE), is characterized by psychiatric symptoms including anxiety and depression upregulated autoantibodies. The B6.Nba2 spontaneous mouse model develops SLE, but has not previously been tested for NPSLE. We investigated NPSLE phenotype in male female mice (n = 12 each) age- sex-matched B6 controls ...

delayed neuronal death after seizure attack may be mediated by the induction of apoptosis-pathway. caspase-3, a mammalian cysteine protease, promotes apoptosis after some neurological disorders. neuron regeneration peptides (nrps) are small synthetic peptides that stimulate neural proliferation, migration, and differentiation with no apparent toxicity and high target specificity in cns. in the ...

Glutamate induces excitotoxic damage to hippocampal pyramidal neurons in Status Epilepticus (SE) and epilepsy. In this study, we investigated time course of dysregulation of calcium homeostasis at various intervals after an episode of SE in acutely isolated CA1hippocampal pyramidal. For this purpose, male Sprague-Dawley rats (200 g) were subjected to pilocarpine-induced SE. The SE was blocked a...