Functional magnetic resonance imaging has demonstrated reorganization of memory encoding networks within the temporal lobe in temporal lobe epilepsy, but little is known of the extra-temporal networks in these patients. We investigated the temporal and extra-temporal reorganization of memory encoding networks in refractory temporal lobe epilepsy and the neural correlates of successful subsequen...

Temporal lobe epilepsy is the most important cause of medically intractable seizures. Complex partial seizures, the main clinical manifestation of temporal lobe epilepsy, arise primarily from the mesial temporal structures, the amygdala, and the hippocampus [1 , 2) . This form of epilepsy is also the most readily treatable with surgery: in most series, recovery is reported in 60-85% of cases [3...

AIMS In temporal lobe epilepsy (TLE) due to hippocampal sclerosis reorganisation in the memory encoding network has been consistently described. Distinct areas of reorganisation have been shown to be efficient when associated with successful subsequent memory formation or inefficient when not associated with successful subsequent memory. We investigated the effect of clinical parameters that mo...

Animal studies and neuropsychological tests of patients with temporal lobe epilepsy have demonstrated the importance of human medial temporal lobes for memory formation. In addition, more recent studies have shown that the human hippocampal region is also involved in novelty detection. However, the exact contribution of the hippocampus proper to these processes is still unknown. To examine furt...

Widespread changes involving neocortical and mesial temporal lobe structures can be present in patients with temporal lobe epilepsy and hippocampal sclerosis. The incidence, pathology, and clinical significance of neocortical temporal lobe sclerosis (TLS) are not well characterized. We identified TLS in 30 of 272 surgically treated cases of hippocampal sclerosis. Temporal lobe sclerosis was def...

PURPOSE To investigate the distribution of MR findings in the hippocampus and amygdala in patients with hippocampal sclerosis. METHODS We blindly evaluated MR scans for atrophy and signal changes occurring in the amygdala, hippocampal head, hippocampal body, and hippocampal tail in 57 consecutive patients with hippocampal sclerosis proved by pathologic analysis. RESULTS Regional atrophy or ...

OBJECTIVE To assess the diagnostic value of the fast FLAIR sequence in patients with epilepsy. METHODS One hundred and twenty eight patients with epilepsy and 10 control subjects were scanned with the fast FLAIR sequence with 5 mm slices, a coronal gradient echo (GRE) T1 weighted sequence with 1.5 mm slices and spin echo (SE) or fast spin echo (FSE) proton density and T2 weighted sequences wi...

BACKGROUND AND PURPOSE Ipsilateral loss of anterior temporal gray-white matter definition, due mainly to white matter signal intensity abnormality, is frequently seen on MR images of patients with hippocampal sclerosis. Our aim was to determine the prevalence and clinical correlations of these anterior temporal changes in pediatric cases of hippocampal sclerosis and to determine whether cumulat...

OBJECTIVE To discuss the treatment effects and costs of surgery and Gamma Knife on hippocampal sclerosis (HS)-induced intractable epilepsy of children below age 10 years. METHODS The children below age 10 years who suffered from HS-induced intractable epilepsy from June 2010 to June 2012 were subjected to surgical and Gamma Knife treatments respectively according to their preference. RESULT...