BACKGROUND : Metronidazole (MTZ) is commonly used as an antibacterial and antiprotozoal drug. Various doses of MTZ have been reported to inhibit spermatogenic activity and sperm indices. MATERIALS AND METHODS In this experimental study, dose-dependent effects of MTZ on the structural and functional integrity of the testis and accessory reproductive organs have been investigated. Adult male mi...

OBJECTIVES To analyze the effects of exposure to hyperoxia (100% oxygen) on the lung histoarchitecture of neonatal mice. METHODS Neonatal Balb/c mice were exposed to hyperoxia (HG) (100% oxygen) (n= 10) in a chamber (15 x 20 x 30 cm) for 24 hours with a flow of 2 L/min. The control group (CG) (n = 10) was exposed to normoxia in the same type of chamber and for the same time. After exposure, t...

Freshwater prawns, Macrobrachium lamarrei (Crustacea-Decapoda) were subjected to static subacute exposure (0.755 mg/l) of detergent, Linear Alkyl Benzene Sulphonate (LAS) (25% 96h LC50) for 10,20 & 30 days. Hepatopancreas showed pronounced changes like vacuolization, hypertrophy, hyperplasia and degenerative leading almost complete loss histoarchitecture after days exposure. Peculiar cell shedd...

17-Trifluoromethyl phenyl trinor prostaglandin F2? (17-TPGF2?) is extracted from a Zinc database, but its value for inhibiting breast cancer (BC) through the substance P (SP)/NK1R system remains unknown. This study was designed to investigate potential antagonist effect of 17-TPGF2? neurokinin 1 receptor (NK1R). The on proliferation and apoptosis BC cell lines determined in vitro lines. Based r...