In agreement with the evolution of histochemistry over the last fifty years and thanks to the impressive advancements in microscopy sciences, the application of cytochemical techniques to light and electron microscopy is more and more addressed to elucidate the functional characteristics of cells and tissue under different physiological, pathological or experimental conditions. Simultaneously, ...

G. Klug, J. Bremicker, T. Kampf, E. Bauer, T. Basse-Lüsebrink, M. Weber, U. Gbureck, U. Nöth, P. M. Jakob, and W. R. Bauer Medizinische Klinik und Poliklinik I, Universitätsklinikum Würzburg, Würzburg, Germany, Experimentelle Physik 5, Universität Würzburg, Würzburg, Germany, Orthopädisches Zentrum für Muskuloskelettale Forschung, Orthopädische Klinik König-Ludwig Haus, Würzburg, Germany, Abtei...

THIS REVIEW is divided into two sections; the first is purely historical, and the second documentary and descriptive in its treatment of modem histochemical methods. Examples of the employment of such methods are given in the second section immediately following the methods to which they refer. The word " modern," in respect of any particular method, refers to usage rather than to origin; never...

  Muscle tissue, skeletal muscle as well as cardiac muscle, is commonly affected in mitochondrial disorders. One explanation for this observation is that muscle tissue has a high-energy demand and therefore is more sensitive to a deficiency of mitochondrial energy production than some other tissues. In mitochondrial disorders, skeletal muscle tissue may be affected primarily by defective respi...