Microglia is the effector cell of the innate immune system in central nervous system (CNS). These cells mediate inflammatory responses in injuries. Besides external factors, microglial function is also controlled by internal factors, including epigenetic regulations. Mechanisms of epigenetic regulation mainly consist of DNA methylation, histone modifications and use of non-coding RNAs. Recent s...

Overexpression of Histone deacetylases as key players in mediating gene expression have been demonstrated to be involved in numerous types of cancer and some isoforms also in neurological, inflammatory and viral pathologies. There is large evidence that histone deacetylase inhibitors can be applied for their treatment. This review summarizes recent clinical aspects and efforts in the drug devel...

patients with acute myeloblastic leukemia (aml) with monosomy 7 are a group of patients with refractory aml who have a very poor prognosis. therefore, rationally designed new therapies, including metronomic chemotherapy regimen with histidine deacetylase inhibitors (valporic acid, atra) are being investigated as potential treatments for the population of refractory cases of aml. herein, we repo...

Mutant p53 is a cancer-specific target for pharmacologic intervention. We show that histone deacetylase inhibitors such as FR901228 and trichostatin A completely depleted mutant p53 in cancer cell lines. This depletion was preceded by induction of p53-regulated transcription. In cells with mutant p53 pretreated with histone deacetylase inhibitors, DNA damage further enhanced the p53 trans-funct...

Histone H2B is deacetylated more rapidly than H3 and H4 in chicken immature erythrocytes. Histone deacetylase from chicken immature erythrocytes was partially purified, and the histone specificities of the multiple histone deacetylase forms were determined. Ion-exchange (Q-Sepharose) and gel-exclusion (Superdex 200) chromatography of extracts from erythrocyte nuclei showed two forms (HD1 and HD...

Histone deacetylase inhibitors are a class of anti-neoplastic agents that induce growth arrest, differentiation, and/or apoptotic cell death of transformed cells in vitro and in vivo. A phase II study exploring the efficacy of romidepsin, an histone deacetylase inhibitor, in patients with cutaneous or peripheral T-cell lymphomas was initiated at the National Cancer Institute. To date, over 120 ...

microglia is the effector cell of the innate immune system in central nervous system (cns). these cells mediate inflammatory responses in injuries. besides external factors, microglial function is also controlled by internal factors, including epigenetic regulations. mechanisms of epigenetic regulation mainly consist of dna methylation, histone modifications and use of non-coding rnas. recent s...

1. Abstract 2. Introduction 2.1. Histone acetyltransferase and deacetylase complexes 2.2. SWI/SNF family of chromatin remodeling complexes 3. Activator targeting of histone acetyltransferase complexes 4. Activator targeting of SWI/SNF complexes 5. Communication between HATs and SWI/SNF at promoter nucleosomes 6. Repressor targeting of histone deacetylase complexes 7. Perspectives 8. Acknowledge...