In addition to being a part of the metabolic fatty acid fuel cycle, butyrate is also capable of inducing growth arrest in a variety of normal cell types and senescence-like phenotypes in gynecological cancer cells, inhibiting DNA synthesis and cell growth in colonic tumor cell lines, suppressing hTERT mRNA expression and telomerase activity in human prostate cancer cells, and inducing stem cell...

Mutations in the WNT/beta-catenin pathway are present in the majority of all sporadic colorectal cancers (CRCs), and histone deacetylase inhibitors induce apoptosis in CRC cells with such mutations. This apoptosis is counteracted by (1) the signaling heterogeneity of CRC cell populations, and (2) the survival pathways induced by mitogens secreted from apoptotic cells. The phenomena of signaling...

Histone deacetylase inhibitors are a class of anti-neoplastic agents that induce growth arrest, differentiation, and/or apoptotic cell death of transformed cells in vitro and in vivo. A phase II study exploring the efficacy of romidepsin, an histone deacetylase inhibitor, in patients with cutaneous or peripheral T-cell lymphomas was initiated at the National Cancer Institute. To date, over 120 ...

Mol. Nutr. Food Res. 2022, 66, 2200164 DOI: 10.1002/mnfr.202200164 Roseburia hominis alleviates neuroinflammation by producing propionate and butyrate, which serve as histone deacetylase inhibitors of microglia. These findings supplied a new solution to reduce manipulating the microbiota. The inspiration image design comes from an ancient Chinese philosophy “Yin-Yang”. This is reported Liping D...

The antitumor activity of the histone deacetylase inhibitors was tested in three well-characterized pancreatic adenocarcinoma cell lines, IMIM-PC-1, IMIM-PC-2, and RWP-1. These cell lines have been previously characterized in terms of their origin, the status of relevant molecular markers for this kind of tumor, resistance to other antineoplastic drugs, and expression of differentiation markers...

We describe a novel two-step approach for the synthesis of compounds with hydroxyl-amide group (hydroxamic acids), which are widely known their biological activity (histone deacetylase inhibitors, matrix metalloproteinases inhibitors and others). The first stage is N-substituted succinimide via reaction aromatic amine or carboxylic acid hydrazide succinic anhydride. second step involves imide r...

conclusions the increasing cell toxicity, apoptosis-inducing effects and decreasing telomerase activity may play an important role in the valproic acid and radiation mechanism. the current survey suggested that it is likely beneficial to combine valproic acid and gamma radiation to treat breast cancer. results combination of valproic acid and gamma radiation increased significantly cell toxicit...