idiopathic inflammatory myopathies are a heterogeneous group of muscle disorders characterized by chronic muscle inflammation and progressive muscle weakness. polymyositis (pm), dermatomyositis (dm) and inclusion body myositis (ibm) are the three major subsets based on distinct clinical and histopathological features. since the pathogenesis remains unclear, therapeutic approaches actually compr...

Granulomatous inflammation in lung biopsies is a relatively non-specific finding that can occur in a range of inflammatory and neoplastic conditions. This review focuses on the patterns of granulomatous inflammation that can cause diffuse lung disease, highlighting histopathological features helpful in differential diagnosis.

Idiopathic inflammatory myopathies are a heterogeneous group of muscle disorders characterized by chronic muscle inflammation and progressive muscle weakness. Polymyositis (PM), dermatomyositis (DM) and inclusion body myositis (IBM) are the three major subsets based on distinct clinical and histopathological features. Since the pathogenesis remains unclear, therapeutic approaches actually compr...

Chronic hepatic inflammation involves a complex interplay of inflammatory and mechanical influences, ultimately manifesting in a characteristic histopathology of liver fibrosis. We created an agent-based model (ABM) of liver tissue in order to computationally examine the consequence of liver inflammation. Our liver fibrosis ABM (LFABM) is comprised of literature-derived rules describing molecul...

Background Interleukin-1 receptor-associated kinase 4 (IRAK-4) is involved in Toll-Like Receptor (TLR) and (IL-1R) signaling pathways regulating innate immunity. Inhibition of IRAK4 could block the expression cytokines autoimmune disorders such as rheumatoid arthritis. CA-4948 a member oxazolopyridine class inhibitors has been shown to suppress TLR agonist-induced NF-kappaB activation, TNF-alph...

Xanthogranulomatous inflammation is a form of chronic inflammatory process with collection foamy macrophages in sheets, often presence giant cell reaction. Here, we present case xanthogranulomatous osteomyelitis tibia 43 years old patient, which rare pathological entity and possibly was reported first 1984. The histopathological sections revealed dense lympho-plasmacytic infiltrate the marrow s...

Isochlorogenic acid C (ICAC) is found in a variety of natural foods and medicinal plant materials. This study aims to validate the biological activity isochlorogenic limiting inflammation by Erk/JNK/NF-κB pathway. In this study, TNF-α-induced human fibroblast-like synoviocytes collagen-induced arthritis animal models were used perceive potential anti-inflammation mechanism ICAC. The role was ev...

Appendicitis is a common clinical problem but not specific to parasite. A 43-year-old patient consulted for digestive troubles, mostly acute abdominal pain, in the right part. Taenia saginata was found appendectomy. Different parasites were histopathological evaluation of appendix, Enterobius vermicularis, also Ascaris, Taenia, amoeba, and Schistosoma. Acute appendicitis proven by submucosal fi...