previous studies have demonstrated some significant differences in hla allele frequencies in leukemic patients and normal subjects. we have analyzed hla class ii alleles and haplotypes in 60 iranian patients with acute myelogenous leukemia (aml) and 180 unrelated normal subjects. blood samples were collected after obtaining informed consents. from the patients and control dna extraction and hla...

Background: The Human Leukocyte Antigen (HLA) is the most polymorphic region in human genome. Moreover, HLA haplotype frequencies are largely used in transplantation, the treatment of autoimmune diseases, and population-based studies. The present study aimed to determine HLA-A, -B, -DR alleles and haplotype frequencies in 88 unrelated donors of Iranian Gilak ethnic group, by Polymerase Chain Re...

Background: Different studies have demonstrated that a small proportion of healthy individuals receiving the hepatitis B (HB) vaccine do not produce protective levels of anti-HB antibody, a phenomenon which could be linked to certain human leukocyte an-tigen (HLA) class-II alleles or haplotypes. Objectives: The present study was under-taken to determine the frequency of HLA class-II alleles in ...

Background: Myasthenia gravis is an autoimmune disorder of neuromuscular junction characterized by skeletal muscle weakness and fatigability. Different genes may control the induction and clinical presentation of this disease. Various HLA alleles are reported as predisposing or protective genetic elements in myasthenia gravis. Objective: The aim of this study was to investigate the probable as...

background and objective: the outcome of hepatitis b virus (hbv) infection may be influenced by host factors like human leukocyte antigen (hla). we have investigated hla-a and drb1 alleles in patients with persistent hepatitis b infection compared to subjects who had spontaneously recovered from hbv infection. to complete the findings of this study we performed another survey in certain hla all...

Background: A common Human Leukocyte Antigen (HLA) class II allele, DQβ1*03:01, seems to be associated with Bullous pemphigoid (BP) in Caucasians whereas previous studies in other ethnic groups showed other HLA class II alleles as genetic predisposing factors for BP. Objective: To investigate the association of HLA class II alleles and haplotypes with BP in Iranian population. Methods: Fifty pa...

objective: survey of the influence of hla-drb1, -dqb1 alleles, genotypes and haplotypes on age at onset of type 1 diabetes (t1d) in an iranian population materials and methods: 105 iranian t1d patients of different ethnic group and 100 ethnically, age and sex matched individuals were selected from tehran's hospitals and hla-drb, -dqb typing was performed. according to the age at onset of t1d, ...

We explored the association between HLA-B and HLA-DRB1 polymorphisms reviewed clinical characteristics of systemic lupus erythematosus (SLE) in Han population Yunnan, China. Methods There were 295 patients 265 healthy control subjects (HCs) enrolled study. Clinical data blood samples collected from patients. The genotypes detected SLE HCs. Results A total 74 on loci determined 288 as well 57 re...

objective: this study aimed to investigate the association between hla alleles and visceral leishmaniasis (vl) in a sample of iraqi patients. methods: a total of 30 patients were studied, in addition to 20 age, gender and ethnicity matched controls. all subjects were genotyped by polymerase chain reaction-sequence specific primers (pcr-ssp) method. results: for hla-class i region (a and b loci)...