Highly purified, detergent-solubilized HLA-A and -B antigens and HLA-D antigens were separately incorporated into liposomes. Detergent-solubilized transplantation antigens, but not papain-solubilized antigens lacking the membrane-integrated portions of the molecules, were bound to the liposomes. A considerable portion of the liposome-bound antigens displayed accessible antigenic sites, suggesti...

PURPOSE To investigate the presence of Human Leukocyte Antigens (HLA) in organ cultured corneas, in lyophilised epikeratophakia lenticules prepared by dry state lathing, and in lenticules subjected to prolonged rehydration in Balanced Salt Solution (BSS). METHODS Twelve lenticules and 3 organ cultured corneas were studied for the presence of HLA-ABC (class I), and HLA-DR, -DQ, and -DP (class ...

Unrelated haematopoietic stem cell transplantation (HSCT) has evolved from an experimental protocol to a potentially curative first-line treatment in variety of haematologic malignancies. The continuous refinement protocols and supportive care paired with ongoing achievements the technological field histocompatibility testing enabled this transformation. Without doubt, HLA matching is still for...

background: in addition to human leukocyte antigens (hla) compatibility, gene polymorphisms in cytokines might also be important in the quality of allogeneic immune response. objective: to evaluate the influence of hla-dr matching and a number of cytokine gene polymorphisms on acute rejection after living-unrelated donor (lurd) kidney transplantation. methods: a total of 42 renal transplants pe...

ulcerative colitis is an acute or chronic inflammatory bowel disease that diffusely involves the colonic mucosa. the etiology of ulcerative colitis is unknown. the involvement of genetic factors in ulcerative colitis is suggested by some reports of familial occurence anil the immune abnormalities found in patients and their unaffected female relatives. a number of disease with unknown etiology,...

The association of HLA and disease varies in different populations. We have . studied the association of HLA class I in Iranian psoriatic patients, in order to compare this association with other reports. Fifty-one Iranian patients with psoriasis were HLA typed. The frequency of HLA antigens in patients and patient subgroups, based on clinical patterns, age of onset, family history and prov...

We studied the distribution of class 1 and class 2 major histocompatibility complex (MHC) antigens on bile duct epithelial cells in liver from patients with primary biliary cirrhosis (PBC) by an immunohistochemical method using monoclonal antibodies to HLA-ABC products and HLA-D subregion products (HLA-DR, -DP, -DQ). By light microscopy, the expression of MHC class 1 antigens (HLA-ABC antigens)...