نتایج جستجو برای: hla class ii alleles
تعداد نتایج: 1020655 فیلتر نتایج به سال:
Background: Pediatric bronchial asthma is associated with considerable morbidity. The study was carried out to examine the association of Human Leukocyte Antigen (HLA)- Class II with the disease as we found no similar study on Asian Indian population. Objective: To define the HLA-Class II antigens in Asian Indian pediatric patients with asthma. Methods: A total of 103 children with asthma and 1...
recurrent aphthous stomatitis (ras) is known as the most common chronic disease of the oral cavity, which affects a range of 5-25% of the population. ras appears to be associated with some human leukocyte antigen (hla) class ii alleles and haplotypes. this study attempts to survey the distribution of hla-drb and -dqb alleles among iranian ras patients and healthy controls. in order to evaluate ...
background: pulmonary tuberculosis (pt) is one of the endemic diseases in iraq, and among the suggested predisposing factors are alleles of the human leukocyte antigen (hla) system. we sought to investigate the association between hla-class i (a and b) and -class ii (dr and dq) alleles in a sample of pt iraqi patients. methods: lymphocytes of 105 pt patients and 40 controls were phenotyped for ...
In unrelated marrow transplantation, the benefit of matching class II HLA-DRB1 and DQB1 alleles of the donor and recipient is well documented. Little is known about the clinical relevance of matching for class I HLA-A, B, and C alleles. We used DNA-amplification methods to identify the HLA-A, B, and C alleles of 300 patients and their donors. The incidence of graft failure was correlated with m...
Human leukocyte antigen (HLA) genes have been associated with susceptibility and protection against a number of cancers. Here we used an immunogenetic epidemiological approach to evaluate the overall influence 127 HLA Class I II alleles on 30 types cancer. We found preponderance protective (negatively correlated cancer prevalences), especially for I. Of cancers investigated, 13 were mostly effe...
objective: this study aimed to investigate the association between hla alleles and visceral leishmaniasis (vl) in a sample of iraqi patients. methods: a total of 30 patients were studied, in addition to 20 age, gender and ethnicity matched controls. all subjects were genotyped by polymerase chain reaction-sequence specific primers (pcr-ssp) method. results: for hla-class i region (a and b loci)...
background the human leukocyte antigen (hla) system is widely used as a strategy in the search for the etiology of renal function impairment. objectives this study was carried out to detect the most common hla alleles’ distribution in kidney transplant in both donors and recipients, and clarify the association between hla alleles and renal dysfunction immediately after transplantation. patients...
Specific HLA class II alleles are strongly associated with susceptibility to rheumatoid arthritis (RA); however, how HLA class II regulates susceptibility to RA has remained unclear. Recently, we found a unique function of HLA class II molecules: their ability to aberrantly transport cellular misfolded proteins to the cell surface without processing to peptides. Rheumatoid factor (RF) is an aut...
background: papillon-lefevre syndrome (pls) is a rare autosomal recessive disorder characterized by palmoplantar hyperkeratosis and early development of aggressive pe-riodontitis. although cathepsin c (ctsc) gene mutations have been established in about 70-80% of pls patients, it is assumed that the patients may have dysfunctioning of immune defense mechanisms. objective: to assess the associat...
Certain HLA-DR alleles confer strong susceptibility to the autoimmune disease rheumatoid arthritis (RA). We compared RA-associated alleles, HLA-DR*0401, HLA-DR*0404, and HLA-DR*0405, with closely related, non-RA-associated alleles, HLA-DR*0402 and HLA-DR*0403, to determine whether they differ in their interactions with the class II chaperone, invariant chain (Ii). Ii binds to class II molecules...
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