A series of structurally related 2,4-dioxopyrimidine-1-carboxamide derivatives as highly potent inhibitors against acid ceramidase were subjected to hologram quantitative structure-activity relationship (HQSAR) analysis. A training set containing 24 compounds served to establish the HQSAR model. The best HQSAR model was generated using atoms, bond, connectivity, donor and acceptor as fragment d...

We report a novel and fast method for converting a digital, complex Fresnel hologram into a phase-only hologram. Briefly, the pixels in the complex hologram are scanned sequentially in a row by row manner. The odd and even rows are scanned from opposite directions, constituting to a bidirectional error diffusion process. The magnitude of each visited pixel is forced to be a constant value, whil...

This paper proposes a method to manipulate digital hologram contents by manipulating and/or synthesizing the depth information. To synthesize digital holograms themselves in order to create new digital hologram contents. This paper uses both the depth information obtained by converting the disparity information by using a stereo matching method and that obtained by taking pictures with a depth ...

Recent reports have brought back the acetylcholine synthesizing enzyme, choline acetyltransferase in the mainstream research in dementia and the cholinergic anti-inflammatory pathway. Here we report, a specific strategy for the design of novel ChAT ligands based on molecular docking, Hologram Quantitative Structure Activity Relationship (HQSAR) and lead optimization. Molecular docking was perfo...

Human plasma protein binding (PPB) is an important pharmacokinetic property in drug design. Hologram quantitative structure-activity relationships (HQSAR) were conducted on a series of structurally diverse molecules with known PPB. The best statistical model (q = 0.72, r = 0.91) was used to predict the PPB of 62 test set compounds, and the predicted values were in good agreement with the experi...

We propose an algorithm that converts a full-parallax hologram to a horizontal-parallax-only (HPO) hologram for 3D display. We first record a full-parallax hologram of an object. Subsequently, we filter the hologram with a Gaussian low-pass filter and a fringe-matched filter along the vertical direction. The final filtered output becomes an HPO hologram. To the best of our knowledge, this is th...

ABSTRUCT Since a general flat hologram has a limited viewable area, we usually cannot see the other side of a reconstructed object. Therefore, we proposed the computer-generated cylindrical hologram as 360 deg viewable display. In this paper, we realize the more entertainment-type computer-generated cylindrical hologram. Since the previous holograms can be displayed is only dead object and it i...

We propose a three-dimensional (3D) holographic display by converting an optically recorded complex full-parallax (FP) hologram to an off-axis horizontal-parallax-only (HPO) hologram. First, we record the complex FP hologram of an object using optical scanning holography. We then convert the complex FP hologram to an off-axis HPO hologram through fringe-matched Gaussian low-pass filtering and w...