The objective of this work was to develop bioadhesive topical gel of Aceclofenac with the help of response-surface approach. Experiments were performed according to a 3-level factorial design to evaluate the effects of two independent variables [amount of Poloxamer 407 (PL-407 = X1) and hydroxypropylmethyl cellulose K100 M (HPMC = X2)] on the bioadhesive character of gel, rheological property o...

1Department of Pharmaceutics, SriVenkateshwara College of Pharmacy and Research center, Affiliated to Osmania University, Madhapur, Hitech City, Hyderabad500081,Andhra Pradesh, India. A b s t r a c t Sitagliptin phosphate when used alone is an oral anti hyperglycemic drug of the dipeptidyl peptidase-4 (DPP-4) inhibitor class. It is available as tablets under trade name JANUVIA. Metformin hydroc...

A sesquiterpene lactone 1-β,10-Epoxy-6-hydroxy-1,10H-inunolide (K100) was isolated through "bioassay-guided fractionation" from Cota palaestina subsp. syriaca, an Eastern Mediterranean endemic plant. K100 inhibited endotoxin- (ET-) induced proinflammatory markers: IL-6, MMP-9, and NO in normal mouse mammary SCp2 Cells. Molecular docking in silico suggested that K100, having highly analogous str...

Aim : This study was aimed to formulate a transdermal matrix patch using green tea leaf extract. Materials and methods The formulation optimized by the simplex lattice design method. correlation between responses analyzed chemometrics. observed were: 1. physical properties of patch, 2. percentage dissolution efficiency catechins, caffeine, epigallocatechin gallate released from patch. determina...

Purpose. Effective Helicobacter pylori eradication requires delivery of the antibiotic locally in the stomach. High dose of amoxicillin (750 to 1000 mg) is difficult to incorporate in floating tablets but can easily be given in liquid dosage form. Keeping the above facts in mind, we made an attempt to develop a new floating in situ gelling system of amoxicillin with increased residence time usi...

The current research focused on screening and finding the significant independent variables in stavudine loaded tablet, followed by optimizing best formulation using central composite design. objective of study to develop controlled release tablet utilizing reduced factorial design, optimization technique as well characterization prepared tablets. Preliminary trial batches were different grades...

For almost two hundred years, diabetes mellitus has been a major health problem worldwide. While there progress in our knowledge of its pathophysiology and treatment, the therapeutic choices available today are woefully inadequate. The goal transdermal medication delivery systems is to provide therapeutically effective doses medicine via skin. released at steady, regulated pace thanks design th...

Floating matrix tablets of losartan potassium were developed with an aim to prolong its gastric residence time and increase the bioavailability of drug. Rapid gastrointestinal transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to diminished efficacy of the administered dose. The tablets were prepared by wet granulation technique, usin...

Agar plates containing antiserum against group B meningococcus or Haemophilus influenzae type b were used to determine the prevalence of cross-reacting K1 and K100 capsular polysaccharide antigens in 265 isolates of disease-causing Escherichia coli. K1 antigen was found in 22% of isolates from various sites. K100 antigen was found in only three isolates. This technique is a convenient method to...

Abstract: Objectives: Female population frequently seeks medical consultation for the vaginal candidiasis. Voriconazole (VOR) is a BCS class II antifungal drug with low aqueous solubility and hence inclusion complex was formulated using Hydroxypropyl-β-cyclodextrin (HPβCD). The incorporated into mucoadhesive tablet Chitosan Hydroxypropyl Methyl Cellulose (HPMC K100). Materials Methods: A 32 ful...