The coordination between cell proliferation and cell death is essential to maintain homeostasis within multicellular organisms. The mechanisms underlying this regulation are yet to be completely understood. Here, we report the identification of hippo (hpo) as a gene that regulates both cell proliferation and cell death in Drosophila. hpo encodes a Ste-20 family protein kinase that binds to and ...

The title compound, Ag(2)Ni(3)(HPO(4))(PO(4))(2), has been synthesized by the hydro-thermal method. Its structure is formed by two types of chains running along the b axis. The first chain results from a linear and continuous succession of NiO(6) octa-hedra linked to PO(4) tetra-hedra by a common vertex. The second chain is built up from two adjacent edge-sharing octa-hedra (dimers) whose ends ...

In order to assess the effectiveness of reconstructed energy dissipation facilities (EDFs) in open channels at hydropower stations, hydraulic prototype observation (HPO) tests are conducted investigate characteristics discharge flow and dynamic response structures during sluice opening periods. While model (HMTs) commonly utilized laboratory settings study these characteristics, experimental co...

Objective: To assess the coverage of the Human Phenotype Ontology (HPO) phenotypes in standard terminologies. Methods: We map HPO terms to the UMLS and its source terminologies and compare these lexical mappings to HPO cross-references. Results: Coverage of HPO classes in UMLS is 54% and 30% in SNOMED CT. Lexical mappings largely outnumber cross-references. Conclusions: Our approach can support...

The principle of optical scanning holography (OSH) is proposed to acquire horizontal-parallax-only (HPO) holographic information electronically. We first briefly summarize the results of OSH and then discuss how HPO-electronic holographic information can be acquired using OSH. Finally we provide simulations to illustrate and clarify the proposed idea. Although many ideas of HPO-holography have ...

Haloperoxidase (HPO, E.C.1.11.1.7) is a metal-containing enzyme oxidizing halonium species, which can be used in the synthesis of halogenated organic compounds, for instance in the production of antimicrobial agents, cosmetics, etc., in the presence of halides and H2O2. To isolate and evaluate a novel non-metal HPO using a culture-independent method, a cassette PCR library was constructed from ...

Objective: To investigate the lexico-syntactic properties of clinical phenotype terms in order to identify partial lexical mappings between HPO and SNOMED CT. Methods: We identify modifiers HPO terms and attempt to map demodified terms to SNOMED CT through UMLS. Results: We identified partial mappings to SNOMED CT for 20% of HPO concepts with no complete mapping to SNOMED CT. Conclusions: Throu...

The Hippo (Hpo) signalling pathway is an evolutionarily conserved pathway controlling tissue growth, but its upstream inputs remain poorly understood. In this issue of The EMBO Journal, Sansores-Garcia et al (2011) report that modulation of filamentous (F)-actin accumulation controls Hpo pathway activity. In a related study, GarciaFernandez et al (2011) confirm this finding, and also show that ...

Hydroperoxide lyases cleave hydroperoxide of linoleic and linolenic acid to form C6-aldehyde and/or C9-aldehyde. These enzymes are widespread in plants [1] but there exist various types of substrate specificity. HPO lyase solubilized from tea chloroplasts can act on 13-HPO but not on 9-HPO [2] and vice versa in the case of the enzyme partially purified from pear fruits [3], Extracts of Phaseolu...

Solavetivone, a potent antifungal phytoalexin, is derived from a vetispirane-type sesquiterpene, premnaspirodiene, by a putative regio- and stereo-specific hydroxylation, followed by a second oxidation to yield the alpha,beta-unsaturated ketone. Mechanistically, these reactions could occur via a single, multifunctional cytochrome P450 or some combination of cytochrome P450s and a dehydrogenase....