Neural development requires both synapse elaboration and elimination, yet relatively little is known about how these opposing activities are coordinated. Here, we provide evidence Hts/Adducin can serve this function. We show that Drosophila Hts/Adducin is enriched both pre- and postsynaptically at the NMJ. We then demonstrate that presynaptic Hts/Adducin is necessary and sufficient to control t...

Motivation: High-throughput screening (HTS) is an early-stage process in drug discovery which allows thousands of chemical compounds to be tested in a single study. We report a method for correcting HTS data prior to the hit selection process (i.e., selection of active compounds). The proposed correction minimizes the impact of systematic errors which may affect the hit selection in HTS. The in...

Heat transfer search (HTS) is a novel metaheuristic optimization algorithm that simulates the laws of thermodynamics and heat transfer. In this study, the HTS algorithm is adapted to truss structure optimization. Sizing optimization searches for the minimum weight of a structure subject to stress and displacement constraints. Three truss structures often taken as benchmarks in the optimization ...

INTRODUCTION Reliable characterization of a hypertrophic scar (HTS) is integral to epidemiologic studies designed to identify clinical and genetic risk factors for HTS. The Vancouver Scar Scale (VSS) has been widely used for this purpose; however, no publication has defined what score on this scale corresponds to a clinical diagnosis of HTS. METHODS In a survey of 1000 burn care providers, we...

The role of c-Src in growth signaling by angiotensin (Ang) II was investigated in vascular smooth muscle cells (VSMCs) from arteries of hypertensive patients. c-Src and extracellular signal-regulated kinase 1/2 (ERK1/2) activity, proto-oncogene expression, activating protein-1 (AP-1) DNA-binding activity, and DNA and protein synthesis were studied in Ang II-stimulated VSMCs derived from small p...

Trauma/hemorrhagic shock is a complex physiological phenomenon that leads to dysregulation of many molecular pathways. For over a decade, hypertonic saline (HTS) has been used as an alternative resuscitation fluid in the setting of trauma/hemorrhagic shock. In addition to restoring circulating volume within the vascular space, studies have shown a positive immunomodulatory effect of HTS. Target...

BACKGROUND Streamlining the timing of treatments in cystic fibrosis (CF) is important to optimise adherence while ensuring efficacy. The optimal timing of treatment with hypertonic saline (HTS) and airway clearance techniques (ACT) is unknown. OBJECTIVES This study hypothesised that HTS before ACT would be more effective than HTS during ACT as measured by Lung Clearance Index (LCI). METHODS...

BACKGROUND The incidence of halitosis has a prevalence of 22-50% throughout the world and is generally caused by anaerobic oral microorganisms, such as Fusobacterium nucleatum, Clostridium perfringens, and Porphyromonas gingivalis. Previous investigations on the structure-activity relationships of ginsenosides have led to contrasting results. Particularly, the antibacterial activity of less pol...

Over the past decade, Hardware Trojans (HTs) research community has made significant progress towards developing effective countermeasures for various types of HTs, yet these countermeasures are shown to be circumvented by sophisticated HTs designed subsequently. Therefore, instead of guaranteeing a certain (low) false negative rate for a small constant set of publicly known HTs, a rigorous sec...

The objective of this work was to compare feedlot performance, carcass characteristics, and beef sensory attributes from steers finished with diets based on corn, high-tannin sorghum (HTS), and a mix of both grains. Angus crossbred steers (n = 11 steers per treatment, initial BW = 404 +/- 18 kg) were finished on diets containing 765 g/kg of DM of corn, HTS, or a 1:1 mix of corn and HTS. Final B...