A sensitive and simple liquid chromatography/electrospray mass spectrometry (LC-ESI-MS) method for determination of ketamine in rabbit plasma using one-step protein precipitation was developed and validated. After addition of methadone as internal standard (IS), protein precipitation by acetonitrile was used as sample preparation. Chromatographically separation was achieved on an SB-C18 (2.1 mm...

A sensitive and simple liquid chromatography/electrospray mass spectrometry (LC-ESI-MS) method for determination of torsemide in rabbit plasma using one-step protein precipitation was developed and validated. After addition of midazolam as internal standard (IS), protein precipitation by acetonitrile was used in sample preparation. Chromatographically separation was achieved on an SB-C18 (2.1 m...

Cnidii Monnieri [Cnidium monnieri (L.) Cusson] is one of the most common used herbal plants in the treatment of numerous ailments including reproductive diseases for hundred of years. Total coumarins of Cnidii Monnieri (TCCM) is a key ingredient. Osthole (Ost) and Imperatorin (Imp) are two main effective ingredients enriched in TCCM. The purpose of this study was to investigate the pharmacokine...

introduction: patients referred to as having thalassemia major are usually those who come to medical attention in the first year of life and subsequently require regular transfusions to survive. those who present later or who seldom need transfusions are said to have thalassemia intermediahydroxyurea, an s-phase-specific and non-dna-hypomethylating chemotherapeutic agents is capable of inducing...

the histone-like protein hu is the most-abundant dna-binding protein in bacteria. the hu protein non-specifically binds and bends dna as a hetero- or homodimer, and can participate in dna supercoiling and dna condensation. it also takes part in dna functions such as replication, recombination, and repair. hu does not recognize any specific sequences but shows a certain degree of specificity to ...

The coupling of the breathing and rotational modes of the skyrmionskyrmion system leads to a nucleon-nucleon spin-orbit interaction of short range, as well as to spin-orbit potentials for the transitionsNN → N(1440)N , NN → NN(1440) and NN → N(1440)N(1440). The longest range behaviour of these spin-orbit potentials is calculated in closed form. Preprint HU-TFT-96-57

We provide a family of polytopes P ⊆ [0, 1] whose Gomory-Chvátal rank is at least ((1 + 1/6)n− 4).

Hydroxyurea (HU) has been successfully used in patients with β-thalassemia intermedia (β-TI). We aimed to evaluate the effect of the long-term use of HU on thyroid function in patients with β-TI. Seventy-five patients with β-TI aged≥11 years and taking HU were randomly selected during 2010 in southern Iran. Thirty-one patients with β-TI without HU were considered as a control group. Serum level...

hydroxyurea (hu) has been successfully used in patients with β-thalassemia intermedia (β-ti). we aimed to evaluate the effect of the long-term use of hu on thyroid function in patients with β-ti. seventy-five patients with β-ti aged≥11 years and taking hu were randomly selected during 2010 in southern iran. thirty-one patients with β-ti without hu were considered as a control group. serum level...